KEGG   ENZYME: 5.3.99.11Help
Entry
EC 5.3.99.11                Enzyme                                 

Name
2-keto-myo-inositol isomerase;
IolI;
inosose isomerase;
2KMI isomerase.
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase
Reaction(IUBMB)
2,4,6/3,5-pentahydroxycyclohexanone = 2D-2,3,5/4,6-pentahydroxycyclohexanone [RN:R09952]
Reaction(KEGG)
Substrate
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691]
Product
2D-2,3,5/4,6-pentahydroxycyclohexanone [CPD:C20251]
Comment
Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
History
EC 5.3.99.11 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K06606  2-keto-myo-inositol isomerase
Genes
ECQ: ECED1_0306
STM: STM4427 STM4435
SEO: STM14_5319 STM14_5326
SEV: STMMW_43711 STMMW_43771
SEY: SL1344_4359(iolI1) SL1344_4365(iolI2)
SEM: STMDT12_C45560 STMDT12_C45620
SEJ: STMUK_4413 STMUK_4420
SEB: STM474_4624 STM474_4631
SEF: UMN798_4794 UMN798_4802
SETU: STU288_22205 STU288_22240
CSK: ES15_3063(iolI)
CTU: CTU_08910
KPN: KPN_04669
KPU: KP1_0551
KPP: A79E_4528
KPE: KPK_4998
KPR: KPR_0646
KPJ: N559_4621
KPX: PMK1_02137(iolI)
KPNU: LI86_23760
KPNK: BN49_4768
KVA: Kvar_4585
KOX: KOX_09355
KOE: A225_0547
EAE: EAE_09790
EAR: CCG32079
YAL: AT01_2636
YFR: AW19_3419
YIN: CH53_1599
YKR: CH54_2371
YRO: CH64_2445
SPE: Spro_4665
SPLY: Q5A_024310
SMW: SMWW4_v1c46180(xylA)
SMAR: SM39_4134
SERF: L085_03355
ETA: ETA_32950(iolI)
EBI: EbC_42710
PAM: PANA_3268
PLF: PANA5342_0800(iolI)
PAJ: PAJ_2487
PVA: Pvag_3029(iolI) Pvag_pPag30220(iolI)
PST: PSPTO_3496(iolI)
PSB: Psyr_3270
PSYR: N018_16410
PFL: PFL_2589(iolL)
PPRC: PFLCHA0_c26540(iolI)
PPRO: PPC_2636(iolL)
PFS: PFLU_2578
PFE: PSF113_2376(iolI)
PFC: PflA506_3032(iolL)
PFW: PF1751_v1c22360(iolI)
PFB: VO64_5690
PMAN: OU5_0764
PSES: PSCI_0434
PSEM: TO66_12605
PSOS: POS17_2594
PANR: A7J50_2469
HCH: HCH_01162
RSO: RSc1245(iolI)
RSN: RSPO_c02128(iolI)
RSE: F504_1273
BCN: Bcen_2074
BCJ: BCAL0918
BCEN: DM39_2775
BCEO: I35_2750
BAM: Bamb_2738
BMU: Bmul_0612
BMJ: BMULJ_02648(iolI)
BMK: DM80_2234
BMUL: NP80_2820
BCED: DM42_2386
BDL: AK34_403
BCON: NL30_26520
BMEC: WJ16_13790
DAC: Daci_2926
LCH: Lcho_3284
MLO: mlr6178
SME: SM_b20711
SMER: DU99_26455
SMD: Smed_4269
SIX: BSY16_215
ATU: Atu4555
ARA: Arad_9586
ATF: Ach5_42510(iolI)
RLE: pRL110624
RLG: Rleg_7181
RHT: NT26_0567
SHZ: shn_13540
MNO: Mnod_7806
HDI: HDIA_1418
PDE: Pden_1677
PSF: PSE_p0065
OTM: OSB_26350
ACR: Acry_2319
AMV: ACMV_25510(iolI) ACMV_P1_01130(iolI)
BSU: BSU39680(iolI)
BSR: I33_4137
BSL: A7A1_1974
BSH: BSU6051_39680(iolI)
BSUT: BSUB_04210(iolI)
BSUL: BSUA_04210(iolI)
BSUS: Q433_21905
BSS: BSUW23_19800(iolI)
BST: GYO_4375
BSO: BSNT_10655(iolI)
BSQ: B657_39680(iolI)
BSX: C663_3887(iolI)
BLI: BL00238(iolI)
BLD: BLi04243(iolI)
BLH: BaLi_c42340(iolI)
BAY: RBAM_036700(iolI)
BAQ: BACAU_3684(iolI)
BYA: BANAU_3854(iolI)
BAMP: B938_18820
BAML: BAM5036_3590(iolI)
BAMA: RBAU_3797(iolI)
BAMN: BASU_3579(iolI)
BAMB: BAPNAU_3861(iolI)
BAMT: AJ82_20705
BAMY: V529_39370(iolI)
BMP: NG74_03844(iolI)
BAO: BAMF_3780(iolI)
BAZ: BAMTA208_19990(iolI)
BQL: LL3_04103(iolI)
BXH: BAXH7_04101(iolI)
BQY: MUS_4359(iolI)
BAMI: KSO_000740
BAMC: U471_38290
BAMF: U722_19550
BATR: TD68_16740
BHA: BH2315(iolI)
BMQ: BMQ_3475(iolI)
BMD: BMD_3469(iolI)
BJS: MY9_4099
BACP: SB24_10410
BACB: OY17_02025
BACY: QF06_18305
BACL: BS34A_42940(iolI)
BALM: BsLM_4011
BEO: BEH_02280
BGY: BGLY_4628(iolI)
GKA: GK1892(iolI)
LRH: LGG_00271(iolI)
LRG: LRHM_0267
LRL: LC705_00262(iolI)
LRA: LRHK_273
CTYK: CTK_C07490
RUM: CK1_18000
FPR: FP2_24950
BPRL: CL2_16300
PFT: JBW_01424
RBA: RB9367(lolI)
TLE: Tlet_1865
 » show all
Taxonomy
Reference
1  [PMID:12112707]
  Authors
Zhang RG, Dementieva I, Duke N, Collart F, Quaite-Randall E, Alkire R, Dieckman L, Maltsev N, Korolev O, Joachimiak A
  Title
Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding.
  Journal
Proteins. 48 (2002) 423-6.
  Sequence
[bsu:BSU39680]
Reference
2  [PMID:16461681]
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H
  Title
Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an  investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
  Journal
Appl. Environ. Microbiol. 72 (2006) 1310-5.
  Sequence
[bsu:BSU39680]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.11
IUBMB Enzyme Nomenclature: 5.3.99.11
ExPASy - ENZYME nomenclature database: 5.3.99.11
BRENDA, the Enzyme Database: 5.3.99.11

DBGET integrated database retrieval system