KEGG   ENZYME: 5.3.99.2Help
Entry
EC 5.3.99.2                 Enzyme                                 

Name
prostaglandin-D synthase;
prostaglandin-H2 Delta-isomerase;
prostaglandin-R-prostaglandin D isomerase;
PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect);
(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase;
prostaglandin endoperoxide Delta-isomerase;
prostaglandin D synthetase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [RN:R02266]
Reaction(KEGG)
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696]
Comment
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
History
EC 5.3.99.2 created 1976, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01830  prostaglandin-H2 D-isomerase
K04097  prostaglandin-H2 D-isomerase / glutathione transferase
Genes
HSA: 27306(HPGDS) 5730(PTGDS)
PTR: 100610452(PTGDS) 743219(HPGDS)
PPS: 100983768(PTGDS) 100990241(HPGDS)
GGO: 101123835(HPGDS) 101130674(PTGDS)
PON: 100442014(HPGDS) 100459419(PTGDS)
NLE: 100592404(PTGDS) 100598180(HPGDS)
MCC: 705227(HPGDS) 707990(PTGDS)
MCF: 101926100(PTGDS) 102131661(HPGDS)
CSAB: 103235987(HPGDS) 103239597(PTGDS)
RRO: 104669645(PTGDS) 104679857(HPGDS)
RBB: 108531868(HPGDS) 108542875(PTGDS)
CJC: 100394436(PTGDS) 100399167(HPGDS)
SBQ: 101033870(PTGDS) 101048967(HPGDS)
MMU: 19215(Ptgds) 54486(Hpgds)
RNO: 25526(Ptgds) 58962(Hpgds)
CGE: 100762704(Ptgds) 100768035(Hpgds)
NGI: 103741183(Ptgds) 103743362(Hpgds)
HGL: 101699559(Ptgds) 101706734(Hpgds)
CCAN: 109700635(Ptgds)
OCU: 100009453 100353701(HPGDS)
TUP: 102482208(PTGDS) 102485301(HPGDS)
CFA: 403740(PTGDS) 478481(HPGDS)
AML: 100466392(HPGDS) 100474593(PTGDS)
UMR: 103675299(PTGDS) 103677906(HPGDS)
ORO: 101372918(PTGDS) 101376365(HPGDS)
FCA: 101083337(HPGDS) 493852(PTGDS)
PTG: 102962017(PTGDS) 102970849(HPGDS)
AJU: 106988526(HPGDS) 106989498(PTGDS)
BTA: 100139892(HPGDS) 286858(PTGDS)
BOM: 102269024(HPGDS) 102274981(PTGDS)
BIU: 109559997(HPGDS) 109566622(PTGDS)
PHD: 102321040 102332351(HPGDS)
CHX: 102191223(HPGDS) 106502686(PTGDS)
OAS: 101116145(HPGDS) 443192(PTGDS)
SSC: 100623584(HPGDS) 397456(PTGDS)
CFR: 102512148(PTGDS) 102513633(HPGDS)
CDK: 105089526(HPGDS) 105106194(PTGDS)
BACU: 103013138(PTGDS) 103019771(HPGDS)
LVE: 103079273(HPGDS) 103088196(PTGDS)
OOR: 101280808(PTGDS) 101285619(HPGDS)
ECB: 100053460(HPGDS) 100067921(PTGDS)
EPZ: 103552392(HPGDS) 103567817(PTGDS)
EAI: 106829529(HPGDS) 106845529(PTGDS)
MYB: 102238842(PTGDS) 102240667(HPGDS)
MYD: 102767586(HPGDS) 102773498(PTGDS)
HAI: 109382064(PTGDS) 109385325(HPGDS)
RSS: 109452269(HPGDS) 109460974(PTGDS)
PALE: 102889838(PTGDS) 102895654(HPGDS)
LAV: 100666840(HPGDS) 100672974(PTGDS)
MDO: 100016454(HPGDS) 100022407(PTGDS)
SHR: 100913465(PTGDS) 100926080(HPGDS)
OAA: 100078645(HPGDS) 100085740
GGA: 374110(PTGDS) 395863(HPGDS)
CJO: 107313254(HPGDS) 107321660
ACYG: 106037158(PTGDS) 106041241(HPGDS)
TGU: 100218607 100224496(HPGDS)
GFR: 102038910 102044676(HPGDS)
FAB: 101805755 101817277(HPGDS)
PHI: 102102732(HPGDS) 102105998(PTGDS)
PMAJ: 107203035(HPGDS) 107212132
CCW: 104688201(PTGDS) 104697200(HPGDS)
FPG: 101912137 101913476(HPGDS)
FCH: 102054810(HPGDS) 102059754
CLV: 102092980 102094022(HPGDS)
EGZ: 104122621(HPGDS) 104123982(PTGDS)
ASN: 102384182(HPGDS) 102385594
AMJ: 102565053(PTGDS) 102574977(HPGDS)
PSS: 102450743(HPGDS) 102450917
CMY: 102940625 102944217(HPGDS)
CPIC: 101934059 101943956(HPGDS)
ACS: 100559774
PBI: 103067226
GJA: 107115167
XLA: 100301961(obp.S) 108698139(cpl-1) 379417(hpgds.S) 397884(ptgds.S) 398969(hpgds.L) 444723(ptgds.L)
XTR: 448666(hpgds) 779694(c8g.2)
DRE: 336492(ptgdsb.1) 751701(ptgdsb.2)
IPU: 100528611(gst28) 108255954 108276825(lcn2)
NCC: 104941618(ptgds) 104965992 104968184(lcn15)
LCM: 102352378(HPGDS) 102359406
CMK: 103184489(hpgds)
SPU: 581825
DME: Dmel_CG8938(GstS1)
DSI: Dsimw501_GD25495(Dsim_GD25495)
MDE: 101890455(GST)
AGA: AgaP_AGAP010404(GST_ANOGA)
AAG: 5575278
AME: 411045(GstS4) 552283 552304(GstS1)
NVI: 100115049(GstS3) 100115470(GstS8) 100115878(GstS7) 100116992(GstS5) 100117248(GstS1) 100120287(GstS4) 100121487(GstS6) 100124012(GstS2)
BMOR: 692543(GSTs2) 692631(GSTs1)
CEL: CELE_R05F9.5(gst-9) CELE_R11G1.3(gst-11) CELE_ZK546.11(gst-30)
CBR: CBG02268(Cbr-gst-9) CBG02278(Cbr-gst-30) CBG14247(Cbr-gst-11)
SHX: MS3_06482
HMG: 100204251
SLA: SERLADRAFT_417671(glt1.1)
SMIN: v1.2.000995.t1(symbB.v1.2.000995.t1) v1.2.003070.t1(symbB.v1.2.003070.t1) v1.2.014814.t1(symbB.v1.2.014814.t1) v1.2.014815.t1(symbB.v1.2.014815.t1) v1.2.017551.t1(symbB.v1.2.017551.t1) v1.2.017577.t1(symbB.v1.2.017577.t1) v1.2.027234.t1(symbB.v1.2.027234.t1) v1.2.040628.t2(symbB.v1.2.040628.t2)
MCG: GL4_2957
 » show all
Taxonomy
Reference
1  [PMID:32914]
  Authors
Christ-Hazelhof E, Nugteren DH.
  Title
Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme.
  Journal
Biochim. Biophys. Acta. 572 (1979) 43-51.
Reference
2  [PMID:109431]
  Authors
Shimizu T, Yamamoto S, Hayaishi O.
  Title
Purification and properties of prostaglandin D synthetase from rat brain.
  Journal
J. Biol. Chem. 254 (1979) 5222-8.
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.2
IUBMB Enzyme Nomenclature: 5.3.99.2
ExPASy - ENZYME nomenclature database: 5.3.99.2
BRENDA, the Enzyme Database: 5.3.99.2
CAS: 65802-85-9

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