KEGG   ENZYME: 5.3.99.4Help
Entry
EC 5.3.99.4                 Enzyme                                 

Name
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN:R02267]
Reaction(KEGG)
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
Comment
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
History
EC 5.3.99.4 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01831  prostacyclin synthase
Genes
HSA: 5740(PTGIS)
PTR: 458323(PTGIS)
PPS: 100987973(PTGIS)
GGO: 101132214(PTGIS) 109025057
PON: 100440673(PTGIS)
NLE: 100592236(PTGIS)
MCC: 703407(PTGIS)
MCF: 102123511(PTGIS)
CSAB: 103244560(PTGIS)
RRO: 104678532(PTGIS)
RBB: 108539469(PTGIS)
CJC: 100403062(PTGIS)
SBQ: 101034236(PTGIS)
MMU: 19223(Ptgis)
RNO: 25527(Ptgis)
CGE: 100757024(Ptgis)
NGI: 103735556(Ptgis)
HGL: 101700601(Ptgis)
CCAN: 109690523(Ptgis)
OCU: 103346149 103352392(PTGIS)
TUP: 102496170(PTGIS)
CFA: 100856661(PTGIS)
AML: 100466540(PTGIS)
UMR: 103669841(PTGIS)
ORO: 101382580(PTGIS)
FCA: 101082050(PTGIS)
PTG: 102952139(PTGIS)
AJU: 106986024(PTGIS)
BTA: 282021(PTGIS)
BOM: 102279286(PTGIS)
PHD: 102317373(PTGIS)
CHX: 100860894(PTGIS)
OAS: 101116418(PTGIS)
SSC: 100126284(PTGIS)
CFR: 102521764(PTGIS)
CDK: 105087868(PTGIS)
BACU: 103018962(PTGIS)
LVE: 103069768(PTGIS)
OOR: 101285307(PTGIS)
ECB: 100071412(PTGIS)
EPZ: 103541173(PTGIS)
EAI: 106825769(PTGIS)
MYB: 102249227(PTGIS)
MYD: 102772939(PTGIS)
HAI: 109381877(PTGIS)
RSS: 109460604(PTGIS)
PALE: 102885283(PTGIS)
LAV: 100669854(PTGIS)
TMU: 101360898
MDO: 100029131(PTGIS)
SHR: 100924178(PTGIS)
OAA: 100076102(PTGIS)
ASN: 102380148(PTGIS)
AMJ: 102570396(PTGIS)
PSS: 102459815(PTGIS)
CMY: 102929462(PTGIS)
CPIC: 101948711(PTGIS)
ACS: 100565699(ptgis)
PVT: 110071794(PTGIS)
PBI: 103056719(PTGIS)
GJA: 107122715
XLA: 108700877(ptgis.L)
XTR: 100492372(ptgis)
NPR: 108803621
DRE: 559148(ptgis)
SGH: 107555969 107561003(ptgis)
IPU: 108271893 108272147(ptgis)
LCO: 104920521 104928129(ptgis)
OLA: 101170919(ptgis)
CSEM: 103385737 103385896(ptgis)
LCF: 108889866(ptgis)
BPEC: 110168753 110168791(ptgis)
ELS: 105017022(ptgis) 105026471
SFM: 108923412 108939002(ptgis)
LCM: 102358660(PTGIS)
CMK: 103190529(ptgis)
 » show all
Taxonomy
Reference
1  [PMID:6338016]
  Authors
DeWitt DL, Smith WL.
  Title
Purification of prostacyclin synthase from bovine aorta by immunoaffinity  chromatography. Evidence that the enzyme is a hemoprotein.
  Journal
J. Biol. Chem. 258 (1983) 3285-93.
Reference
2  [PMID:7023490]
  Authors
Ullrich V, Castle L, Weber P.
  Title
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase.
  Journal
Biochem. Pharmacol. 30 (1981) 2033-6.
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.4
IUBMB Enzyme Nomenclature: 5.3.99.4
ExPASy - ENZYME nomenclature database: 5.3.99.4
BRENDA, the Enzyme Database: 5.3.99.4
CAS: 65802-86-0

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