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Entry
EC 5.4.1.4                  Enzyme                                 

Name
D-galactarolactone isomerase;
GLI
Class
Isomerases;
Intramolecular transferases;
Transferring acyl groups
BRITE hierarchy
Sysname
D-galactaro-1,5-lactone isomerase (D-galactaro-1,4-lactone-forming)
Reaction(IUBMB)
D-galactaro-1,5-lactone = D-galactaro-1,4-lactone [RN:R10846]
Reaction(KEGG)
Substrate
D-galactaro-1,5-lactone [CPD:C20889]
Product
D-galactaro-1,4-lactone [CPD:C20896]
Comment
The enzyme, characterized from the bacterium Agrobacterium fabrum strain C58, belongs to the amidohydrolase superfamily. It participates in the degradation of D-galacturonate.
History
EC 5.4.1.4 created 2015
Pathway
ec00053  Ascorbate and aldarate metabolism
Orthology
K18982  D-galactarolactone isomerase
Genes
PCH: EY04_12420
CSA: Csal_2475
HEL: HELO_3406
HAK: KO116_03369
HAM: HALO3642
MME: Marme_0066
MPC: Mar181_2907
MARS: A8C75_18895
CBW: RR42_m2140
BTE: BTH_II0981
BTQ: BTQ_4276
BTJ: BTJ_5314
BTZ: BTL_3776
BTV: BTHA_4107
BTHE: BTN_3882
BTHM: BTRA_3773
BTHA: DR62_3924
BTHL: BG87_3732
BCN: Bcen_3836
BCJ: BCAM1714
BCEO: I35_5584
BCT: GEM_3925
BCED: DM42_6235
BCON: NL30_03600
BSEM: WJ12_28490
BPSL: WS57_05430
BMEC: WJ16_27325
BGO: BM43_5639
BPH: Bphy_6996
BPT: Bpet3816
ODI: ODI_R3125
POL: Bpro_4571
MES: Meso_1945
ATU: Atu3138
ATF: Ach5_29930(gli)
XAU: Xaut_3369
PHL: KKY_3039
 » show all
Taxonomy
Reference
1  [PMID:24450804]
  Authors
Bouvier JT, Groninger-Poe FP, Vetting M, Almo SC, Gerlt JA.
  Title
Galactaro delta-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.
  Journal
Biochemistry. 53 (2014) 614-6.
  Sequence
[atu:Atu3138]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.1.4
IUBMB Enzyme Nomenclature: 5.4.1.4
ExPASy - ENZYME nomenclature database: 5.4.1.4
BRENDA, the Enzyme Database: 5.4.1.4

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