KEGG   ENZYME: 5.4.3.10Help
Entry
EC 5.4.3.10                 Enzyme                                 

Name
phenylalanine aminomutase (L-beta-phenylalanine forming)
Class
Isomerases;
Intramolecular transferases;
Transferring amino groups
BRITE hierarchy
Sysname
L-phenylalanine 2,3-aminomutase [(R)-3-amino-3-phenylpropanoate forming]
Reaction(IUBMB)
L-phenylalanine = L-beta-phenylalanine [RN:R10286]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079]
Product
L-beta-phenylalanine [CPD:C20487]
Comment
The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO). This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.11, phenylalanine aminomutase (D-beta-phenylalanine forming).
History
EC 5.4.3.10 created 2013
Reference
1  [PMID:21361343]
  Authors
Feng L, Wanninayake U, Strom S, Geiger J, Walker KD
  Title
Mechanistic, mutational, and structural evaluation of a Taxus phenylalanine aminomutase.
  Journal
Biochemistry. 50 (2011) 2919-30.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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