KEGG   ENZYME: 5.4.3.11Help
Entry
EC 5.4.3.11                 Enzyme                                 

Name
phenylalanine aminomutase (D-beta-phenylalanine forming);
admH (gene name);
L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate]
Class
Isomerases;
Intramolecular transferases;
Transferring amino groups
BRITE hierarchy
Sysname
L-phenylalanine 2,3-aminomutase [(S)-3-amino-3-phenylpropanoate-forming]
Reaction(IUBMB)
L-phenylalanine = D-beta-phenylalanine [RN:R10287]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079]
Product
D-beta-phenylalanine [CPD:C20488]
Comment
The enzyme from the bacterium Pantoea agglomerans produces D-beta-phenylalanine, an intermediate in the biosynthesis of the polyketide non-ribosomal antibiotic andrimid. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine. cf. EC 5.4.3.10, phenylalanine aminomutase (L-beta-phenylalanine forming).
History
EC 5.4.3.11 created 2013
Reference
1  [PMID:21561099]
  Authors
Ratnayake ND, Wanninayake U, Geiger JH, Walker KD
  Title
Stereochemistry and mechanism of a microbial phenylalanine aminomutase.
  Journal
J. Am. Chem. Soc. 133 (2011) 8531-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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