KEGG ENZYME: 5.4.3.2

KEGG

ENZYME: 5.4.3.2

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Entry

EC 5.4.3.2 Enzyme

Name

lysine 2,3-aminomutase

Class

Isomerases;
Intramolecular transferases;
Transferring amino groups

BRITE hierarchy

Sysname

L-lysine 2,3-aminomutase

Reaction(IUBMB)

L-lysine = (3S)-3,6-diaminohexanoate [RN:R00461]

Reaction(KEGG)

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Substrate

L-lysine [CPD:C00047]

Product

(3S)-3,6-diaminohexanoate [CPD:C01142]

Comment

Activity is stimulated by S-adenosyl-L-methionine and pyridoxal phosphate.

Pathway

Lysine degradation

Orthology

lysine 2,3-aminomutase

Genes

NCR:	NCU02663
PAN:	PODANSg2033
SSL:	SS1G_07889
BFU:	BC1G_07782
AFV:	AFLA_005130
PNO:	SNOG_07493
BAB:	bbp022(yjeK)
SGL:	SG0308
ENT:	Ent638_0332
DDC:	Dd586_0022
HIT:	NTHI0447
HSO:	HS_1288
VFI:	VF_2339(yjeK)
PSP:	PSPPH_4554
PAR:	Psyc_1679(kamA)
PCR:	Pcryo_1949
PRW:	PsycPRwf_0487
SSE:	Ssed_1818
CPS:	CPS_0971
PHA:	PSHAa0473(kamA)
PIN:	Ping_3283
FBL:	Fbal_1216
TCX:	Tcr_1742
NOC:	Noc_2627
AEH:	Mlg_0683 Mlg_1185
DNO:	DNO_0590(kamA)
RMA:	Rmag_0322
VOK:	COSY_0303(kamA)
BCN:	Bcen_5091
BCH:	Bcen2424_5769
RFR:	Rfer_3891
GSU:	GSU1754(yjeK)
GME:	Gmet_1840(yjeK)
GUR:	Gura_2149
GLO:	Glov_2103
GBM:	Gbem_2398(kamA)
GEO:	Geob_2781
GEM:	GM21_1821
PCA:	Pcar_1401(ablA) Pcar_2520(yjeK)
PPD:	Ppro_1079 Ppro_1765
DDE:	Dde_0189 Dde_2747 Dde_3041
DSA:	Desal_2912 Desal_3316
DAS:	Daes_0845
DBA:	Dbac_0211 Dbac_1776
DRT:	Dret_0696
BBA:	Bd3344(kamA)
BMX:	BMS_0668 BMS_1706
DPS:	DP2159 DP2204
DAK:	DaAHT2_0565 DaAHT2_1378 DaAHT2_2229
DPR:	Despr_2357
DOL:	Dole_1893 Dole_2513
DAL:	Dalk_2594 Dalk_3854
DAT:	HRM2_03800(kamA1) HRM2_13250(kamA2) HRM2_29300
ADE:	Adeh_2547 Adeh_2548
ACP:	A2cp1_1402 A2cp1_1403
AFW:	Anae109_1315 Anae109_1316
ANK:	AnaeK_1301 AnaeK_1302
MXA:	MXAN_4698(kamA) MXAN_4699
SUR:	STAUR_5548(kamA) STAUR_5549
SCL:	sce2448(kamA1) sce7261(kamA2)
HOH:	Hoch_0181 Hoch_3939
SAT:	SYN_00182 SYN_02634
SFU:	Sfum_0711 Sfum_4018
DBR:	Deba_0212
HMR:	Hipma_0096
MLO:	mll1971 mlr5971
SME:	SMc00355
SMD:	Smed_3476
RHI:	NGR_c36130
ATU:	Atu2555(kamA)
ARA:	Arad_4637(kamA)
AVI:	Avi_6024(kamA)
AGR:	AGROH133_08690(kamA)
RET:	RHE_CH04042(kamA)
REC:	RHECIAT_CH0004331(kamA)
RLE:	RL4598
RLT:	Rleg2_3797
RLG:	Rleg_4126
LAS:	CLIBASIA_04835(kamA)
BJA:	blr4388
BRA:	BRADO3588
BBT:	BBta_4014
RPA:	RPA2515(kamA)
RPB:	RPB_2954
RPC:	RPC_2807
RPD:	RPD_2506
RPE:	RPE_2928
RPT:	Rpal_2794
NWI:	Nwi_1641
NHA:	Nham_2300
OCA:	OCAR_6026
XAU:	Xaut_3908
AZC:	AZC_2928
SNO:	Snov_2125
MEX:	Mext_3003
MEA:	Mex_1p3211
MDI:	METDI3775
MCH:	Mchl_3228
MRD:	Mrad2831_2740
MET:	M446_0377
MPO:	Mpop_3192
MNO:	Mnod_1886
BID:	Bind_3223
MSL:	Msil_0453
HDN:	Hden_1435
CCR:	CC_0716
CCS:	CCNA_00753
CAK:	Caul_0763
CSE:	Cseg_3667
PZU:	PHZ_c2669
RSP:	RSP_3227
RSH:	Rsph17029_3965
RSQ:	Rsph17025_3212
RSK:	RSKD131_3407
RCP:	RCAP_rcc00394(kamA)
PDE:	Pden_1666
KVU:	EIO_2476
HNE:	HNE_3138
HBA:	Hbal_0029
GOX:	GOX0234
GBE:	GbCGDNIH1_1087
ACR:	Acry_2376
GDI:	GDI_0508
GDJ:	Gdia_1499
APT:	APA01_02760
RRU:	Rru_A0224
RCE:	RC1_2506(kamA)
MAG:	amb1284
AZL:	AZL_026200(kamA)
BSU:	BSU19690(kamA)
BSS:	BSUW23_10535(kamA)
BLI:	BL01430(kamA)
BLD:	BLi02294(kamA)
BAO:	BAMF_2048(kamA)
BAY:	RBAM_019520(kamA)
BAE:	BATR1942_08565
BHA:	BH2255
BAN:	BA_2300(kamA)
BAR:	GBAA_2300(kamA)
BAT:	BAS2145
BAH:	BAMEG_2294(kamA)
BAI:	BAA_2364(kamA)
BAL:	BACI_c22610(kamA)
BCE:	BC2251
BCA:	BCE_2334(kamA)
BCZ:	BCZK2079(kamA)
BCR:	BCAH187_A2408(kamA)
BCB:	BCB4264_A2281(kamA)
BCU:	BCAH820_2325(kamA)
BCG:	BCG9842_B3042(kamA)
BCQ:	BCQ_2234(kamA)
BCX:	BCA_2381(kamA)
BCY:	Bcer98_1688
BTK:	BT9727_2083(kamA)
BTL:	BALH_2062
BTB:	BMB171_C2029(kamA)
BWE:	BcerKBAB4_2118
BPU:	BPUM_1892(kamA)
BPF:	BpOF4_18615(yodO)
BMQ:	BMQ_2377(kamA) BMQ_4040
BMD:	BMD_2339(kamA) BMD_4025
LSP:	Bsph_3298
BBE:	BBR47_55020(kamA)
CTC:	CTC00890
CPY:	Cphy_1643
CSH:	Closa_2267
CCB:	Clocel_2678
CDF:	CD630_22520(kamA)
CDC:	CD196_2109(kamA)
CDL:	CDR20291_2152(kamA)
CST:	CLOST_1382(kamA)
AMT:	Amet_2738 Amet_4552
AOE:	Clos_0418
STH:	STH35
SWO:	Swol_1121
SLP:	Slip_1437
DSY:	DSY4027
DHD:	Dhaf_1337
DRM:	Dred_0740 Dred_2148
DAE:	Dtox_0599 Dtox_0600 Dtox_2931
PTH:	PTH_0616(KamA)
DAU:	Daud_0171 Daud_1068
TJR:	TherJR_1812
SGY:	Sgly_2707
CLE:	Clole_3465
OVA:	OBV_12600(kamA)
TTE:	TTE0723(KamA) TTE1204(KamA2)
CHY:	CHY_2479
MTA:	Moth_0457
ADG:	Adeg_1408
CSC:	Csac_0232
ATE:	Athe_2274
COB:	COB47_2039
CHD:	Calhy_0483
COW:	Calow_1972
CKI:	Calkr_2290
CKN:	Calkro_0356
NTH:	Nther_1768 Nther_1886 Nther_2886
AAR:	Acear_1280
ICA:	Intca_1789
MPH:	MLP_08640
NCA:	Noca_2661
KFL:	Kfla_3605
TFU:	Tfu_0272
TCU:	Tcur_2339
SVI:	Svir_21810
AMD:	AMED_4735(kamA)
AMI:	Amir_3716 Amir_4485
STP:	Strop_2262
SAQ:	Sare_2381
MAU:	Micau_3119
MIL:	ML5_5276
VMA:	VAB18032_20365
SNA:	Snas_3953
SSM:	Spirs_3983
LIL:	LA_2701(kamA) LB_298
LIC:	LIC11303 LIC20230(kamA)
LBJ:	LBJ_2006(kamA) LBJ_4222(kamA)
LBL:	LBL_1044(kamA) LBL_4236(kamA)
LBI:	LEPBI_I1797(kamA) LEPBI_II0202(kamA)
LBF:	LBF_1744(kamA) LBF_4195(kamA)
BTH:	BT_4474
BFR:	BF3578
BFS:	BF3383
BVU:	BVU_2729
PGI:	PG1070(kamA)
PGN:	PGN_1166
PDI:	BDI_0607
OSP:	Odosp_3173
SRU:	SRU_1133
SRM:	SRM_01310(kamA)
RMR:	Rmar_0136
FNU:	FN1866
IPO:	Ilyop_0443 Ilyop_2505
OTE:	Oter_1916
CAA:	Caka_2005
MIN:	Minf_0017(kamA)
RBA:	RB1214(kamA)
PSL:	Psta_3379
ACO:	Amico_0185
TLI:	Tlie_0336 Tlie_1391
CPC:	Cpar_1400
CPB:	Cphamn1_1421 Cphamn1_1649
CLI:	Clim_1455
PVI:	Cvib_1367
PLT:	Plut_1576
PAA:	Paes_0802
DET:	DET0221 DET0628
DEH:	cbdb_A219(kamA) cbdb_A615(kamA)
DEB:	DehaBAV1_0133 DehaBAV1_0601
DEV:	DhcVS_197(ablAB) DhcVS_569
DEG:	DehalGT_0266 DehalGT_0563
DLY:	Dehly_0994
ATM:	ANT_25010(kamA)
DRA:	DR_A0027
DGE:	Dgeo_0988
DDR:	Deide_09030
DMR:	Deima_1983
AAE:	aq_454
HYA:	HY04AAS1_0099
HTH:	HTH_0327(kamA)
TAL:	Thal_0524
SUL:	SYO3AOP1_0796
SAF:	SULAZ_0064
PMX:	PERMA_0346
TAM:	Theam_1077
DTE:	Dester_0538
TPT:	Tpet_0803
TLE:	Tlet_0488
TME:	Tmel_0192
TAF:	THA_424
FNO:	Fnod_0207
PMO:	Pmob_1080
KOL:	Kole_0963
MPZ:	Marpi_0478
NDE:	NIDE3574(kamA)
DDF:	DEFDS_1850(kamA)
DAP:	Dacet_0802 Dacet_0867
FSI:	Flexsi_0712
MJA:	MJ_0634
MFE:	Mefer_0245
MVU:	Metvu_0851
MFS:	MFS40622_1045
MIF:	Metin_0158
MIG:	Metig_0413
MMP:	MMP0861(kamA)
MMQ:	MmarC5_0609 MmarC5_0666 MmarC5_1350
MMX:	MmarC6_1795
MMZ:	MmarC7_0106 MmarC7_1783
MAE:	Maeo_0240
MVN:	Mevan_1195 Mevan_1223
MAC:	MA3979
MBA:	Mbar_A0670
MMA:	MM_0934
MBU:	Mbur_0186 Mbur_0274
MMH:	Mmah_0483 Mmah_1439
MZH:	Mzhil_0344 Mzhil_1041
MLA:	Mlab_0345
MEM:	Memar_0215
MPI:	Mpet_1464
MPD:	MCP_1919
RCI:	RRC148
APO:	Arcpr_1032
TON:	TON_1269
TBA:	TERMP_00188
IHO:	Igni_1382

Taxonomy

Reference

1

Authors

Aberhart, D.J., Lim, H.-J. and Weiller, B.H.

Title

Stereochemistry of lysine 2,3-aminomutase.

Journal

J. Am. Chem. Soc. 103 (1981) 6750-6752.

Reference

2 [PMID:5452674]

Authors

Zappia V, Barker HA.

Title

Studies on lysine-2,3-aminomutase. Subunit structure and sulfhydryl groups.

Journal

Biochim. Biophys. Acta. 207 (1970) 505-13.

Organism

Clostridium sp.

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

9075-20-1

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RPAIR (1)   
   KEGG RCLASS (1)   
Gene (6996)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (365)   
   KEGG EGENES (4)   
   KEGG MGENES (6626)   
Protein sequence (1422)   
   UniProt (722)   
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   RefSeq(pep) (657)   
   PDBSTR (4)   
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DNA sequence (1437)   
   RefSeq(nuc) (614)   
   GenBank (410)   
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Enzyme (4)   
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