tRNA pseudouridine13 synthase;
TruD;
YgbO;
tRNA PSI13 synthase;
RNA:PSI-synthase Pus7p;
Pus7p;
RNA:pseudouridine-synthase Pus7p;
Pus7 protein

Isomerases;
Intramolecular transferases;
Transferring other groups

tRNA-uridine13 uracil mutase

tRNA uridine13 = tRNA pseudouridine13

tRNA uridine13

Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA [2,3]. The Pus7 protein from Saccharomyces cerevisiae is a multisite-multisubstrate pseudouridine synthase that is able to modify uridine13 in several yeast tRNAs, uridine35 in the pre-tRNATyr, uridine35 in U2 small nuclear RNA, and uridine50 in 5S rRNA [5].

1  [PMID:15135053]

Ericsson UB, Nordlund P, Hallberg BM

X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold.

FEBS. Lett. 565 (2004) 59-64.

2  [PMID:19664587]

Chan CM, Huang RH

Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases.

Arch. Biochem. Biophys. 489 (2009) 15-9.

3  [PMID:12756329]

Kaya Y, Ofengand J

A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya.

RNA. 9 (2003) 711-21.

4  [PMID:14561887]

Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C

The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs.

RNA. 9 (2003) 1371-82.

5  [PMID:19114708]

Urban A, Behm-Ansmant I, Branlant C, Motorin Y

RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p.

J. Biol. Chem. 284 (2009) 5845-58.