KEGG   ENZYME: 5.4.99.3Help
Entry
EC 5.4.99.3                 Enzyme                                 

Name
2-acetolactate mutase;
acetolactate mutase;
acetohydroxy acid isomerase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
2-acetolactate methylmutase
Reaction(IUBMB)
2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate [RN:R03052]
Reaction(KEGG)
R03052 > R05071;
(other) R05069
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Substrate
2-acetolactate [CPD:C00900]
Product
3-hydroxy-3-methyl-2-oxobutanoate [CPD:C04181]
Comment
Requires ascorbic acid; also converts 2-aceto-2-hydroxybutanoate to 3-hydroxy-3-methyl-2-oxopentanoate.
History
EC 5.4.99.3 created 1972
Pathway
Valine, leucine and isoleucine biosynthesis
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Reference
1  [PMID:4384955]
  Authors
Allaudeen HS, Ramakrishnan T.
  Title
Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37 Rv.
  Journal
Arch. Biochem. Biophys. 125 (1968) 199-209.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37318-52-8

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