KEGG   ENZYME: 5.4.99.32Help
Entry
EC 5.4.99.32                Enzyme                                 

Name
protostadienol synthase;
PdsA;
(S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3beta-ol [RN:R09689]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
(17Z)-protosta-17(20),24-dien-3beta-ol [CPD:C19820]
Comment
(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.
History
EC 5.4.99.32 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15811  
protostadienol synthase
Genes
NFI: 
AFM: 
Taxonomy
Reference
1  [PMID:19216560]
  Authors
Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP
  Title
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.
  Journal
Org. Lett. 11 (2009) 1241-4.
  Organism
Aspergillus fumigatus [GN:afm]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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