KEGG   ENZYME: 5.4.99.4Help
Entry
EC 5.4.99.4                 Enzyme                                 

Name
2-methyleneglutarate mutase;
alpha-methyleneglutarate mutase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
2-methyleneglutarate carboxy-methylenemethylmutase
Reaction(IUBMB)
2-methyleneglutarate = 2-methylene-3-methylsuccinate [RN:R03908]
Reaction(KEGG)
Substrate
2-methyleneglutarate [CPD:C02930]
Product
2-methylene-3-methylsuccinate [CPD:C02295]
Comment
Requires a cobamide coenzyme.
History
EC 5.4.99.4 created 1972
Pathway
Nicotinate and nicotinamide metabolism
Reference
1  [PMID:5266166]
  Authors
Kung HF, Cederbaum S, Tsai L, Stadtman TC.
  Title
Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 65 (1970) 978-84.
Reference
2  [PMID:5574401]
  Authors
Kung HF, Stadtman TC.
  Title
Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase.
  Journal
J. Biol. Chem. 246 (1971) 3378-88.
  Sequence
[up:Q59268]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-10-3

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