KEGG   ENZYME: 5.4.99.40Help
Entry
EC 5.4.99.40                Enzyme                                 

Name
alpha-amyrin synthase;
2,3-oxidosqualene alpha-amyrin cyclase;
mixed amyrin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = alpha-amyrin [RN:R06471]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
alpha-amyrin [CPD:C08615]
Comment
A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).
History
EC 5.4.99.40 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15815  
lupeol synthase 2
Genes
ATH: 
AT1G78960(LUP2)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
Taxonomy
Reference
1  [PMID:10848960]
  Authors
Morita M, Shibuya M, Kushiro T, Masuda K, Ebizuka Y
  Title
Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase.
  Journal
Eur. J. Biochem. 267 (2000) 3453-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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