KEGG   ENZYME: 5.4.99.50Help
Entry
EC 5.4.99.50                Enzyme                                 

Name
friedelin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = friedelin [RN:R09910]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
friedelin [CPD:C08626]
Comment
The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.
History
EC 5.4.99.50 created 2011
Reference
1  [PMID:20610397]
  Authors
Wang Z, Yeats T, Han H, Jetter R
  Title
Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids.
  Journal
J. Biol. Chem. 285 (2010) 29703-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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