KEGG   ENZYME: 5.4.99.54Help
Entry
EC 5.4.99.54                Enzyme                                 

Name
beta-seco-amyrin synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-seco-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-seco-amyrin [RN:R09914]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
beta-seco-amyrin [CPD:C20193]
Comment
The enzyme from Arabidopsis thaliana is multifunctional and produces about equal amounts of alpha- and beta-seco-amyrin. See EC 5.4.99.52, alpha-seco-amyrin synthase.
History
EC 5.4.99.54 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K16204  
seco-amyrin synthase
Genes
ATH: 
ALY: 
BRP: 
Taxonomy
Reference
1  [PMID:17263431]
  Authors
Shibuya M, Xiang T, Katsube Y, Otsuka M, Zhang H, Ebizuka Y
  Title
Origin of structural diversity in natural triterpenes: direct synthesis of seco-triterpene skeletons by oxidosqualene cyclase.
  Journal
J. Am. Chem. Soc. 129 (2007) 1450-5.
  Sequence
[ath:AT1G78500]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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