KEGG   ENZYME: 5.4.99.63Help
Entry
EC 5.4.99.63                Enzyme                                 

Name
ethylmalonyl-CoA mutase;
Ecm
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(2R)-ethylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA [RN:R09292]
Reaction(KEGG)
Substrate
(2R)-ethylmalonyl-CoA [CPD:C20238]
Product
(2S)-methylsuccinyl-CoA [CPD:C18324]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires coenzyme B12 for activity.
History
EC 5.4.99.63 created 2015
Pathway
Glyoxylate and dicarboxylate metabolism
Orthology
K14447  
ethylmalonyl-CoA mutase
Genes
GPB: 
APP: 
PLA: 
BOP: 
BOS: 
BVV: 
XAU: 
AZC: 
MEX: 
MEA: 
MDI: 
MCH: 
MRD: 
MET: 
MPO: 
MNO: 
MOR: 
META: 
MAQU: 
CHEL: 
HDN: 
HDT: 
HMC: 
HNI: 
RVA: 
FIL: 
FIY: 
BVR: 
RHZ: 
MSC: 
MCG: 
RBM: 
CCR: 
CCS: 
CAK: 
CSE: 
CHQ: 
CBOT: 
SIL: 
SIT: 
RMB: 
RSP: 
RSP_0961(MeaA)
RSH: 
RSQ: 
RSK: 
RCP: 
JAN: 
RDE: 
RD1_1635(mutB)
RLI: 
PDE: 
PAMI: 
DSH: 
Dshi_2855(mutB)
PSF: 
PSE_0116(mutB)
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
OTM: 
OSB_04900(mutB)
LMD: 
RED: 
PTP: 
CID: 
CMAR: 
MALG: 
CON: 
RSU: 
PPHR: 
HAT: 
LAP: 
DAA: 
YAN: 
HNE: 
HBA: 
HBC: 
RRU: 
RRF: 
RPM: 
MAG: 
MGY: 
MAGX: 
TMO: 
TMO_0118(meaA)
TXI: 
MAGQ: 
PGV: 
SCO: 
SCO6472(SC9C7.08c)
SMA: 
SAV_1912(meaA1)
SGR: 
SGB: 
SCB: 
SSX: 
SVL: 
SCT: 
SCAT_4858(meaA)
SCY: 
SFA: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SALB: 
SALS: 
STRP: 
SFI: 
SCI: 
SRC: 
SALU: 
SALL: 
SLV: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
STRM: 
STRC: 
SAMB: 
SPRI: 
SCZ: 
SCX: 
SRW: 
TUE45_07074(mutB_2)
STRF: 
SLE: 
sle_13030(sle_13030)
KSK: 
KSE_56500(meaA)
ICA: 
ARS: 
NCA: 
NDK: 
I601_3918(mutB_2)
KFL: 
PSIM: 
AER: 
FRA: 
FRE: 
FRI: 
FAL: 
FRAAL5921(meaA)
FSY: 
GOB: 
BSD: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
AJA: 
AMQ: 
ALU: 
PDX: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
PHH: 
SESP: 
BN6_73420(meaA)
KAL: 
KPHY: 
LED: 
ALL: 
STP: 
SAQ: 
MAU: 
MIL: 
CAI: 
CWO: 
AFO: 
AYM: 
ABAI: 
LIL: 
LB_074(mcm2)
LIE: 
LIC: 
LIC_20058(mcm2)
LIS: 
LIL_20066(mcm1)
LBJ: 
LBJ_4062(meaA)
LBL: 
LBL_4062(meaA)
LBI: 
LBF: 
LBF_4043(meaA)
LST: 
TPX: 
 » show all
Taxonomy
Reference
1  [PMID:18819910]
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE.
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J. Biol. Chem. 283 (2008) 32283-93.
  Sequence
[rsp:RSP_0961]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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