KEGG   ENZYME: 5.4.99.63Help
Entry
EC 5.4.99.63                Enzyme                                 

Name
ethylmalonyl-CoA mutase;
Ecm
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(2R)-ethylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA [RN:R09292]
Reaction(KEGG)
Substrate
(2R)-ethylmalonyl-CoA [CPD:C20238]
Product
(2S)-methylsuccinyl-CoA [CPD:C18324]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires coenzyme B12 for activity.
History
EC 5.4.99.63 created 2015
Reference
1  [PMID:18819910]
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE.
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J. Biol. Chem. 283 (2008) 32283-93.
  Sequence
[rsp:RSP_0961]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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