KEGG   ENZYME: 5.4.99.63Help
Entry
EC 5.4.99.63                Enzyme                                 

Name
ethylmalonyl-CoA mutase;
Ecm
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(2R)-ethylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA [RN:R09292]
Reaction(KEGG)
Substrate
(2R)-ethylmalonyl-CoA [CPD:C20238]
Product
(2S)-methylsuccinyl-CoA [CPD:C18324]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires coenzyme B12 for activity.
History
EC 5.4.99.63 created 2015
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
Orthology
K14447  ethylmalonyl-CoA mutase
Genes
KAK: Kalk_01785
OME: OLMES_2175
GPB: HDN1F_15990(smbA)
APP: CAP2UW1_2499
PLA: Plav_1625
BOP: AXW83_14150
BOS: BSY19_4455
BVV: BHK69_28685
XAU: Xaut_1197
AZC: AZC_0992
MEX: Mext_0290
MEA: Mex_1p0180(ecm)
MDI: METDI0163(ecm)
MCH: Mchl_0334
MET: M446_0036
MPO: Mpop_0366
MNO: Mnod_0038
MOR: MOC_1330
META: Y590_00905
MAQU: Maq22A_1p32005(meaA)
HDN: Hden_0218
HMC: HYPMC_0095(ecm)
RVA: Rvan_1142
FIL: BN1229_v1_1371(meaA)
FIY: BN1229_v1_1370(meaA)
BVR: BVIR_89
MSC: BN69_1950
MCG: GL4_3338
HDI: HDIA_3962(scpA_2)
RBM: TEF_03475
CCR: CC_3081
CAK: Caul_0836
CSE: Cseg_3643
SIL: SPO0368
RSP: RSP_0961(MeaA)
RCP: RCAP_rcc03241(mutB)
JAN: Jann_0797
RDE: RD1_1635(mutB)
RLI: RLO149_c030730(mutB2)
PDE: Pden_3875
DSH: Dshi_2855(mutB)
PSF: PSE_0116(mutB)
PGA: PGA1_c03840(mutB)
PGL: PGA2_c03390(mutB)
PGD: Gal_03117
PHP: PhaeoP97_02971(mutB)
PPIC: PhaeoP14_00302(mutB)
OAT: OAN307_c41380(mutB2)
OAR: OA238_c04410(mutB1)
OTM: OSB_04900(mutB)
PTP: RCA23_c09170(mcmA1)
CID: P73_3853
MALG: MALG_02725
RSU: NHU_00738
RHC: RGUI_0611
SPSE: SULPSESMR1_00407(scpA)
RMM: ROSMUCSMR3_01834(scpA)
LVS: LOKVESSMR4R_02788(mutB)
HNE: HNE_3115
HBA: Hbal_0291
RRU: Rru_A3062
RRF: F11_15685
MAG: amb0310
MGY: MGMSRv2__2673(yliK)
MAGX: XM1_1238
MAGN: WV31_14305
TMO: TMO_0118(meaA)
TXI: TH3_17590
MAGQ: MGMAQ_3101
SCO: SCO6472(SC9C7.08c)
SMA: SAVERM_1912(meaA1)
SGR: SGR_1171
SGB: WQO_29555
SCT: SCAT_4858(meaA)
SFA: Sfla_0906
SBH: SBI_02837
SHY: SHJG_7433
SVE: SVEN_6306
SDV: BN159_1953(meaA)
SALB: XNR_0457
SALS: SLNWT_0465
STRP: F750_5948
SFI: SFUL_6326
SALU: DC74_6486
SALL: SAZ_33455
SLV: SLIV_06065(meaA)
SGU: SGLAU_27250(meaA)
STRE: GZL_02324
SLD: T261_1718
STRM: M444_27575
SAMB: SAM23877_6066(meaA)
SPRI: SPRI_1331
SRW: TUE45_07074(mutB_2)
SLE: sle_13030(sle_13030)
SRN: A4G23_04916(scpA_5)
SNR: SNOUR_10730(meaA)
STRD: NI25_06040
SMAL: SMALA_6100
SLAU: SLA_6260
SALF: SMD44_07017(ecm)
SALJ: SMD11_1339(ecm)
SLX: SLAV_08025(mutB1)
KSK: KSE_56500(meaA)
NCA: Noca_1772
NDK: I601_3918(mutB_2)
KFL: Kfla_5026
PSIM: KR76_10535
FAL: FRAAL5921(meaA)
GOB: Gobs_4128
BSD: BLASA_3911(mutB)
AMD: AMED_7761
AMN: RAM_39870
AMM: AMES_7643
AMZ: B737_7643
AOI: AORI_6548(ecm)
AJA: AJAP_06220(meaA)
AMQ: AMETH_1366(mutB)
PDX: Psed_1691
PSEA: WY02_10790
PSEE: FRP1_03360
PSEH: XF36_19370
SESP: BN6_73420(meaA)
KAL: KALB_7597
ALL: CRK59015
SAQ: Sare_4003
MIL: ML5_3195
CAI: Caci_1226
CWO: Cwoe_4193
AFO: Afer_0223
AYM: YM304_38140(meaA)
LIL: LB_074(mcm2)
LIE: LIF_B059(sbm)
LIC: LIC_20058(mcm2)
LIS: LIL_20066(mcm1)
LBJ: LBJ_4062(meaA)
LBL: LBL_4062(meaA)
LBI: LEPBI_II0044(mcm2)
LBF: LBF_4043(meaA)
LST: LSS_18738
 » show all
Taxonomy
Reference
1  [PMID:18819910]
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE.
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J. Biol. Chem. 283 (2008) 32283-93.
  Sequence
[rsp:RSP_0961]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.63
IUBMB Enzyme Nomenclature: 5.4.99.63
ExPASy - ENZYME nomenclature database: 5.4.99.63
BRENDA, the Enzyme Database: 5.4.99.63

DBGET integrated database retrieval system