| Entry |
|
|---|
| Name |
dichloromuconate cycloisomerase |
|---|
| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) |
|---|
| Reaction(IUBMB) |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate =
2,4-dichloro-cis,cis-muconate [RN:R04345] |
|---|
| Reaction(KEGG) |
R04345;
(other) R05393
 |
|---|
| Substrate |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04625] |
|---|
| Product |
2,4-dichloro-cis,cis-muconate [CPD:C03918] |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
Requires Mn2+. The product of cycloisomerization of
dichloro-cis,cis-muconate spontaneously eliminates chloride to
produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts,
in the reverse direction, on cis,cis-muconate and its
monochloro-derivatives, but with lower affinity. Not identical with
EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate
cycloisomerase). |
|---|
| Pathway |
PATH: ec00627 1,4-Dichlorobenzene degradation |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2327971]
Kuhm AE, Schlomann M, Knackmuss HJ, Pieper DH.
Purification and characterization of dichloromuconate cycloisomerase
from Alcaligenes eutrophus JMP 134.
Biochem. J. 266 (1990) 877-83.
Alcaligenes eutrophus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.5.1.11
IUBMB Enzyme Nomenclature: 5.5.1.11
ExPASy - ENZYME nomenclature database: 5.5.1.11
UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.11
BRENDA, the Enzyme Database: 5.5.1.11
CAS: 126904-95-8 |
|---|
