KEGG   ENZYME: 5.5.1.11Help
Entry
EC 5.5.1.11                 Enzyme                                 

Name
dichloromuconate cycloisomerase;
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Reaction(IUBMB)
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate [RN:R04345]
Reaction(KEGG)
R04345;
(other) R05393
Show
Substrate
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04625]
Product
2,4-dichloro-cis,cis-muconate [CPD:C03918]
Comment
Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate cycloisomerase).
History
EC 5.5.1.11 created 1992
Pathway
Chlorocyclohexane and chlorobenzene degradation
Microbial metabolism in diverse environments
Reference
1  [PMID:2327971]
  Authors
Kuhm AE, Schlomann M, Knackmuss HJ, Pieper DH.
  Title
Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134.
  Journal
Biochem. J. 266 (1990) 877-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
126904-95-8

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