KEGG   ENZYME: 5.5.1.13Help
Entry
EC 5.5.1.13                 Enzyme                                 

Name
ent-copalyl diphosphate synthase;
ent-kaurene synthase A;
ent-kaurene synthetase A;
ent-CDP synthase;
ent-copalyl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
ent-copalyl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = ent-copalyl diphosphate [RN:R02068]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
ent-copalyl diphosphate [CPD:C06089]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase)
History
EC 5.5.1.13 created 2002
Pathway
Diterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K04120  
ent-copalyl diphosphate synthase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
101214392(CsCPS1)
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0002s05300g(POPTRDRAFT_798561) POPTR_0005s23190g(POPTRDRAFT_761211)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4329013(CPS1) 9266189(OsCyc2)
DOSA: 
Os02t0278700-01(Os02g0278700) Os02t0570900-00(Os02g0570900) Os02t0571100-01(Os02g0571100) Os04t0178300-01(Os04g0178300)
OBR: 
BDI: 
SBI: 
SORBI_01g021990(SORBIDRAFT_01g021990)
ZMA: 
103641248(GRMZM2G068808) 103655054 103655056 542165(an2) 542253(an1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
 » show all
Taxonomy
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J. Biol. Chem. 246 (1971) 6913-28.
Reference
2  [PMID:7994182]
  Authors
Sun TP, Kamiya Y.
  Title
The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
  Journal
Plant. Cell. 6 (1994) 1509-18.
  Sequence
[ath:AT4G02780]
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y.
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J. Biol. Chem. 272 (1997) 21706-12.
  Sequence
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T.
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci. Biotechnol. Biochem. 64 (2000) 660-4.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9055-64-5

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