KEGG   ENZYME: 5.5.1.14Help
Entry
EC 5.5.1.14                 Enzyme                                 

Name
syn-copalyl-diphosphate synthase;
OsCyc1;
OsCPSsyn;
syn-CPP synthase;
syn-copalyl diphosphate synthase;
9alpha-copalyl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
9alpha-copalyl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = 9alpha-copalyl diphosphate [RN:R06312]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
9alpha-copalyl diphosphate [CPD:C11902]
Comment
Requires a divalent metal ion, preferably Mg2+, for activity. This class II terpene synthase produces syn-copalyl diphosphate, a precursor of several rice phytoalexins, including oryzalexin S and momilactones A and B. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme is constitutively expressed in the roots of plants where one of its products, momilactone B, acts as an allelochemical (a molecule released into the environment to suppress the growth of neighbouring plants). In other tissues the enzyme is upregulated by conditions that stimulate the biosynthesis of phytoalexins.
History
EC 5.5.1.14 created 2008
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12928  
aphidicolan-16beta-ol synthase/syn-copalyl-diphosphate synthase
K14043  
syn-copalyl-diphosphate synthase
Genes
OSA: 
4335090(CPS4)
SBI: 
SORBI_05g022290(SORBIDRAFT_05g022290)
Taxonomy
Reference
1  [PMID:15341631]
  Authors
Otomo K, Kenmoku H, Oikawa H, Konig WA, Toshima H, Mitsuhashi W, Yamane H, Sassa T, Toyomasu T.
  Title
Biological functions of ent- and syn-copalyl diphosphate synthases in rice: key enzymes for the branch point of gibberellin and phytoalexin biosynthesis.
  Journal
Plant. J. 39 (2004) 886-93.
  Sequence
[osa:4335090]
Reference
2  [PMID:15255861]
  Authors
Xu M, Hillwig ML, Prisic S, Coates RM, Peters RJ.
  Title
Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.
  Journal
Plant. J. 39 (2004) 309-18.
  Sequence
[osa:4335090]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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