KEGG   ENZYME: 5.5.1.16Help
Entry
EC 5.5.1.16                 Enzyme                                 

Name
halimadienyl-diphosphate synthase;
Rv3377c;
halimadienyl diphosphate synthase;
tuberculosinol diphosphate synthase;
halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing);
halima-5,13-dien-15-yl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
halima-5,13-dien-15-yl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = tuberculosinyl diphosphate [RN:R09715]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
tuberculosinyl diphosphate [CPD:C19836]
Comment
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).
History
EC 5.5.1.16 created 2008, modified 2012
Orthology
K17811  
halimadienyl-diphosphate synthase
Genes
MTU: 
MTV: 
MTC: 
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
KPHY: 
 » show all
Taxonomy
Reference
1  [PMID:15719101]
  Authors
Nakano C, Okamura T, Sato T, Dairi T, Hoshino T.
  Title
Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.
  Journal
Chem. Commun. (Camb).  (2005) 1016-8.
  Sequence
[mtu:Rv3377c]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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