KEGG   ENZYME: 5.5.1.17Help
Entry
EC 5.5.1.17                 Enzyme                                 

Name
(S)-beta-macrocarpene synthase;
TPS6;
TPS11;
(S)-beta-macrocarpene lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(S)-beta-macrocarpene lyase (ring-opening)
Reaction(IUBMB)
(S)-beta-bisabolene = (S)-beta-macrocarpene [RN:R09625]
Reaction(KEGG)
Substrate
(S)-beta-bisabolene [CPD:C19751]
Product
(S)-beta-macrocarpene [CPD:C19752]
Comment
The synthesis of (S)-beta-macrocarpene from (2E,6E)-farnesyl diphosphate proceeds in two steps. The first step is the cyclization to (S)-beta-bisabolene (cf. EC 4.2.3.55, (S)-beta-bisabolene synthase). The second step is the isomerization to (S)-beta-macrocarpene.
History
EC 5.5.1.17 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K15797  
(S)-beta-macrocarpene synthase
Genes
BDI: 
ZMA: 
103641097(Umi3) 542688(tps6)
SITA: 
Taxonomy
Reference
1  [PMID:18524777]
  Authors
Kollner TG, Schnee C, Li S, Svatos A, Schneider B, Gershenzon J, Degenhardt J
  Title
Protonation of a neutral (S)-beta-bisabolene intermediate is involved in (S)-beta-macrocarpene formation by the maize sesquiterpene synthases TPS6 and TPS11.
  Journal
J. Biol. Chem. 283 (2008) 20779-88.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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