KEGG   ENZYME: 5.5.1.20Help
Entry
EC 5.5.1.20                 Enzyme                                 

Name
prosolanapyrone-III cycloisomerase;
Sol5 (ambiguous);
SPS (ambiguous);
solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
prosolanapyrone-III:(-)-solanapyrone A isomerase
Reaction(IUBMB)
prosolanapyrone III = (-)-solanapyrone A [RN:R09918]
Reaction(KEGG)
Substrate
prosolanapyrone III [CPD:C19934]
Product
(-)-solanapyrone A [CPD:C20201]
Comment
The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 1.1.3.42, prosolanapyrone II oxidase).
History
EC 5.5.1.20 created 2011
Orthology
K20550  
prosolanapyrone-II oxidase / prosolanapyrone-III cycloisomerase
Reference
1  [PMID:20486243]
  Authors
Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I
  Title
Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide  synthase encoded in a biosynthetic gene cluster from Alternaria solani.
  Journal
Chembiochem. 11 (2010) 1245-52.
  Sequence
Reference
2  [PMID:9659400]
  Authors
Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A
  Title
Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction.
  Journal
Biochim. Biophys. Acta. 1384 (1998) 387-95.
  Sequence
Reference
3  [PMID:18256508]
  Authors
Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H
  Title
Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani.
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 604-7.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system