KEGG   ENZYME: 5.5.1.24Help
Entry
EC 5.5.1.24                 Enzyme                                 

Name
tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
delta/gamma-tocopherol lyase (ring-opening)
Reaction(IUBMB)
(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]
Reaction(KEGG)
Substrate
delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]
Product
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]
Comment
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
History
EC 5.5.1.24 created 2013
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09834  tocopherol cyclase
Genes
ATH: AT4G32770(VTE1)
ALY: ARALYDRAFT_491430
CRB: 17877607
CSAT: 104716894 104720514 104721549 104729992
EUS: EUTSA_v10025006mg
BRP: 103862197
BNA: 106411207 106423312 106423394
BOE: 106301700
THJ: 104803808
CPAP: 110822117
CIT: 102615028
TCC: 18587955
DZI: 111302940
EGR: 104437768
VRA: 106762339
VAR: 108318687
CCAJ: 109801639
CAM: 101502250
ADU: 107470774
LJA: Lj0g3v0238379.1(Lj0g3v0238379.1) Lj0g3v0307759.1(Lj0g3v0307759.1)
LANG: 109339295
FVE: 101304641
PPER: 18791199
PMUM: 103320200
PAVI: 110761173
CSV: 101206720
CMO: 103488188
MCHA: 111004926
CMAX: 111496186
CMOS: 111454510
CPEP: 111799319
RCU: 8271188
JCU: 105638244
HBR: 110669879
VVI: 100268095
SLY: 101263925
SPEN: 107026784
SOT: 102577462(SXD1)
CANN: 107839135
NSY: 104221249
NTO: 104098970
INI: 109178717
SIND: 105164753
OEU: 111385234
HAN: 110873807
LSV: 111907085
DCR: 108225390
BVG: 104885180
SOE: 110775274
NNU: 104595147
OSA: 4329007
DOSA: Os02t0276500-01(Os02g0276500)
OBR: 102712058
BDI: 100846924
ATS: 109734383(LOC109734383)
SBI: 8060379
ZMA: 541877(sxd1)
SITA: 101764913
PDA: 103702550
EGU: 105040851
MUS: 103995049
DCT: 110106522
AOF: 109821288
ATR: 18426679
APRO: F751_1103
PTI: PHATRDRAFT_bd1025(VTE1)
FCY: FRACYDRAFT_242143(VTE1)
SYN: slr1737
SYY: SYNGTS_1199(slr1737)
SYT: SYNGTI_1199(slr1737)
SYS: SYNPCCN_1198(slr1737)
SYQ: SYNPCCP_1198(slr1737)
CYA: CYA_0654
CYB: CYB_0605
AMR: AM1_2430
MAR: MAE_59750
MPK: VL20_741
CYT: cce_3689
TER: Tery_1802
GVI: glr3089
GLJ: GKIL_0805
ANA: all0245
AVA: Ava_2735
NAZ: Aazo_3505
CALH: IJ00_12110
CTHE: Chro_1644
 » show all
Taxonomy
Reference
1  [PMID:12213958]
  Authors
Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.
  Title
Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12495-500.
  Sequence
[ath:AT4G32770]
Reference
2  [PMID:12913173]
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant. Physiol. 132 (2003) 2184-95.
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.24
IUBMB Enzyme Nomenclature: 5.5.1.24
ExPASy - ENZYME nomenclature database: 5.5.1.24
BRENDA, the Enzyme Database: 5.5.1.24

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