KEGG   ENZYME: 5.5.1.24Help
Entry
EC 5.5.1.24                 Enzyme                                 

Name
tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
delta/gamma-tocopherol lyase (ring-opening)
Reaction(IUBMB)
(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]
Reaction(KEGG)
Substrate
delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]
Product
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]
Comment
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
History
EC 5.5.1.24 created 2013
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K09834  
tocopherol cyclase
Genes
ATH: 
AT4G32770(VTE1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
SPEN: 
SOT: 
102577462(SXD1)
SIND: 
BVG: 
NNU: 
OSA: 
4329007(OsJ_06237)
DOSA: 
Os02t0276500-01(Os02g0276500)
OBR: 
BDI: 
SBI: 
SORBI_04g010660(SORBIDRAFT_04g010660)
ZMA: 
541877(sxd1)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
PTI: 
TPS: 
AAF: 
EHX: 
SYN: 
SYZ: 
SYY: 
SYNGTS_1199(slr1737)
SYT: 
SYNGTI_1199(slr1737)
SYS: 
SYNPCCN_1198(slr1737)
SYQ: 
SYNPCCP_1198(slr1737)
SYJ: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
MAR: 
MPK: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
AMR: 
DSL: 
HAO: 
GLP: 
CMP: 
TER: 
LEP: 
LEN: 
LET: 
GEI: 
OAC: 
ONI: 
PSEU: 
CEP: 
MIC: 
ARP: 
GVI: 
GLJ: 
ANA: 
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
CTHE: 
PLP: 
SCS: 
FIS: 
 » show all
Taxonomy
Reference
1  [PMID:12213958]
  Authors
Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.
  Title
Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12495-500.
  Sequence
[ath:AT4G32770]
Reference
2  [PMID:12913173]
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant. Physiol. 132 (2003) 2184-95.
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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