KEGG   ENZYME: 5.5.1.26Help
Entry
EC 5.5.1.26                 Enzyme                                 

Name
nogalonic acid methyl ester cyclase;
methyl nogalonate cyclase;
SnoaL (gene name);
methyl nogalonate lyase (cyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
nogalaviketone lyase (ring-opening)
Reaction(IUBMB)
nogalaviketone = methyl nogalonate [RN:R09328]
Reaction(KEGG)
Substrate
nogalaviketone [CPD:C18630]
Product
methyl nogalonate [CPD:C12415]
Comment
The enzyme, characterized from the bacterium Streptomyces nogalater, is involved in the biosynthesis of the aromatic polyketide nogalamycin.
History
EC 5.5.1.26 created 2015
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15943  
nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase
Genes
MAU: 
MIL: 
Taxonomy
Reference
1  [PMID:15071504]
  Authors
Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G.
  Title
Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.
  Journal
EMBO. J. 23 (2004) 1911-21.
Reference
2  [PMID:15159574]
  Authors
Sultana A, Kallio P, Jansson A, Niemi J, Mantsala P, Schneider G
  Title
Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 1118-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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