KEGG   ENZYME: 6.2.1.10Help
Entry
EC 6.2.1.10                 Enzyme                                 

Name
carboxylic acid---CoA ligase (GDP-forming);
acyl-CoA synthetase (GDP-forming);
acyl coenzyme A synthetase (guanosine diphosphate forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
carboxylic acid:CoA ligase (GDP-forming)
Reaction(IUBMB)
GTP + a carboxylate + CoA = GDP + phosphate + acyl-CoA [RN:R00394]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
carboxylate [CPD:C00060];
CoA [CPD:C00010]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009];
acyl-CoA [CPD:C00040]
History
EC 6.2.1.10 created 1972, modified 2011
Reference
1  [PMID:14213337]
  Authors
ROSSI CR, GIBSON DM.
  Title
ACTIVATION OF FATTY ACIDS BY A GUANOSINE TRIPHOSPHATE-SPECIFIC THIOKINASE FROM LIVER MITOCHONDRIA.
  Journal
J. Biol. Chem. 239 (1964) 1694-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37318-59-5

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