KEGG   ENZYME: 6.2.1.11Help
Entry
EC 6.2.1.11                 Enzyme                                 

Name
biotin---CoA ligase;
biotinyl-CoA synthetase;
biotin CoA synthetase;
biotinyl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
biotin:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA [RN:R01075]
Reaction(KEGG)
R01075;
(other) R01074 R03762
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Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
biotinyl-CoA [CPD:C01894]
History
EC 6.2.1.11 created 1972
Pathway
Biotin metabolism
Metabolic pathways
Reference
1  [PMID:14257635]
  Authors
CHRISTNER JE, SCHLESINGER MJ, COON MJ.
  Title
ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION.
  Journal
J. Biol. Chem. 239 (1964) 3997-4005.
  Organism
Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37318-60-8

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