KEGG   ENZYME: 6.2.1.13Help
Entry
EC 6.2.1.13                 Enzyme                                 
Name
acetate---CoA ligase (ADP-forming);
acetyl-CoA synthetase (ADP-forming);
acetyl coenzyme A synthetase (adenosine diphosphate-forming);
acetate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
acetate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA [RN:R00229]
Reaction(KEGG)
R00229;
(other) R00920
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Substrate
ATP [CPD:C00002];
acetate [CPD:C00033];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024]
Comment
Also acts on propanoate and, very slowly, on butanoate.
Pathway
Glycolysis / Gluconeogenesis
Pyruvate metabolism
Propanoate metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01905  
acetyl-CoA synthetase (ADP-forming)
Genes
BMA: 
BMV: 
BML: 
BMN: 
BPS: 
BPM: 
BPL: 
BPD: 
BPZ: 
BPQ: 
BTE: 
BTH_II2206
BGL: 
bglu_2g22010
BGD: 
bgla_2g28900
BPE: 
BP0661
BBR: 
BB4797
VEI: 
Veis_3495
BBT: 
BBta_7760
CHY: 
CHY_0264
MMP: 
MMP0253(acd)
MPD: 
MCP_0448(acdB)
MEZ: 
Mtc_1390(acdB)
RCI: 
RCIX1773(acdB) RCIX1774(acdA)
PHO: 
PH1517 PH1739
PAB: 
PAB0203(sucC-like) PAB1937
PFU: 
PF1540 PF1787
PFI: 
PFC_06930 PFC_09655
PYN: 
PNA2_0103 PNA2_0342
PYA: 
PYCH_01760 PYCH_07600
PYS: 
Py04_1410 Py04_1668
TKO: 
TK0465 TK0665
TON: 
TON_0327 TON_1097
TGA: 
TGAM_1201(acdA-5) TGAM_1288(acdB-2)
TSI: 
TSIB_0529 TSIB_1099
TBA: 
TERMP_00768 TERMP_01102
THE: 
GQS_03615 GQS_10055
THA: 
TAM4_1967 TAM4_2077
THM: 
CL1_0374 CL1_1587
ABI: 
Aboo_0320
SMR: 
Smar_0449 Smar_1242
SHC: 
Shell_0356 Shell_1213
DKA: 
DKAM_0725 DKAM_0846 DKAM_0929
DMU: 
Desmu_0132 Desmu_0402 Desmu_0896
DFD: 
Desfe_0782 Desfe_0977 Desfe_1050
TAG: 
Tagg_0143 Tagg_0340 Tagg_0726
IAG: 
Igag_1584 Igag_1585
THG: 
TCELL_0066 TCELL_0712
HBU: 
Hbut_0152 Hbut_1336 Hbut_1337
PFM: 
Pyrfu_1410 Pyrfu_1411
PAI: 
PAE3249
PIS: 
Pisl_0485
PCL: 
Pcal_1855
PAS: 
Pars_1805
PYR: 
P186_1420
POG: 
Pogu_0325
CMA: 
Cmaq_1092
TNE: 
Tneu_1634
TUZ: 
TUZN_1460
TTN: 
TTX_2015(acd)
VDI: 
Vdis_2379
VMO: 
VMUT_0727
TPE: 
Tpen_0602
FFO: 
FFONT_0734 FFONT_1213
KCR: 
Kcr_0115 Kcr_0198
 » show all
Taxonomy
Reference
1  [PMID:13076]
  Authors
Reeves RE, Warren LG, Susskind B, Lo HS.
  Title
An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.
  Journal
J. Biol. Chem. 252 (1977) 726-31.
  Organism
Entamoeba histolytica [GN:ehi]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62009-85-2
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