KEGG   ENZYME: 6.2.1.15Help
Entry
EC 6.2.1.15                 Enzyme                                 
Name
arachidonate---CoA ligase;
arachidonoyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
arachidonate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA [RN:R01598]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
arachidonate [CPD:C00219];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
arachidonoyl-CoA [CPD:C02249]
Comment
Not identical with EC 6.2.1.3 long-chain-fatty-acid---CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate.
Reference
1  [PMID:7061494]
  Authors
Wilson DB, Prescott SM, Majerus PW.
  Title
Discovery of an arachidonoyl coenzyme A synthetase in human platelets.
  Journal
J. Biol. Chem. 257 (1982) 3510-5.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82047-87-8
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