KEGG ENZYME: 6.2.1.16

KEGG

ENZYME: 6.2.1.16

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Entry

EC 6.2.1.16 Enzyme

Name

acetoacetate---CoA ligase;
acetoacetyl-CoA synthetase

Class

Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases

BRITE hierarchy

Sysname

acetoacetate:CoA ligase (AMP-forming)

Reaction(IUBMB)

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA [RN:R01357]

Reaction(KEGG)

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Substrate

ATP [CPD:C00002];
acetoacetate [CPD:C00164];
CoA [CPD:C00010]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
acetoacetyl-CoA [CPD:C00332]

Comment

Also acts, more slowly, on L-3-hydroxybutanoate.

Pathway

Butanoate metabolism

Orthology

acetoacetyl-CoA synthetase

Genes

HSA:	65985(AACS)
PTR:	452361(AACS)
PPS:	100983892(AACS)
GGO:	101125277(AACS)
PON:	100432798(AACS)
MCC:	707015(AACS)
MMU:	78894(Aacs)
RNO:	65984(Aacs)
CFA:	486240(AACS)
AML:	100474264
FCA:	101082951(AACS)
BTA:	505842(AACS)
SSC:	100156545
ECB:	100061661
MDO:	100020461
SHR:	100918094(AACS)
OAA:	100076424
GGA:	416811(AACS)
MGP:	100550304
TGU:	100231447(AACS)
ACS:	100552271
XTR:	734109(aacs)
DRE:	393984(aacs)
TRU:	101069004
OLA:	101168218
BFO:	BRAFLDRAFT_84438
CIN:	100185593
SPU:	590598(AACS)
CEL:	CELE_K03A1.5(sur-5)
CBR:	CBG11014(Cbr-sur-5)
NVE:	NEMVE_v1g170196
HMG:	100215976
TAD:	TRIADDRAFT_26822
CME:	CMT445C
NCR:	NCU00446 NCU01378
SMP:	SMAC_01882 SMAC_04065
PAN:	PODANSg5078 PODANSg8712
TTT:	THITE_2107278 THITE_43789
MTM:	MYCTH_2092688 MYCTH_2301077
MGR:	MGG_05196 MGG_12999
FGR:	FG04103.1 FG06090.1
NHE:	NECHADRAFT_101654 NECHADRAFT_43638
VAL:	VDBG_04101
SSL:	SS1G_11391
BFU:	BC1G_02728 BC1G_08841
ANI:	AN1103.2 AN1482.2
NFI:	NFIA_013650 NFIA_097550
AFM:	AFUA_1G11880 AFUA_8G04770
AOR:	AOR_1_1168174(AO090005000672) AOR_1_648164(AO090001000376)
ANG:	ANI_1_594074(An08g04090)
AFV:	AFLA_067790 AFLA_079190
ACT:	ACLA_023720 ACLA_058160
PCS:	Pc13g10810 Pc22g00960
CIM:	CIMG_09061
CPW:	CPC735_008520 CPC735_014980
PBL:	PAAG_08217 PAAG_08892
URE:	UREG_03325 UREG_07181
ABE:	ARB_00069 ARB_04342
TVE:	TRV_00935 TRV_03202
AJE:	HCAG_00472 HCAG_01294
PNO:	SNOG_10057
PTE:	PTT_12115 PTT_19912
ZTR:	MYCGRDRAFT_66126 MYCGRDRAFT_68224 MYCGRDRAFT_74664
TML:	GSTUM_00008048001
CNB:	CNBE4890
CGI:	CGB_E6460C
PPL:	POSPLDRAFT_89541
LBC:	LACBIDRAFT_230952 LACBIDRAFT_313724
MPR:	MPER_03496 MPER_09529
CCI:	CC1G_00323 CC1G_04522
SCM:	SCHCODRAFT_63001
UMA:	UM00285.1 UM05131.1
MGL:	MGL_1606
VCH:	VCA0829
VCE:	Vch1786_II0519(acs-2)
VCJ:	VCD_000496
VCO:	VC0395_0406(acs-2)
VCR:	VC395_A0853(acs-2)
VCM:	VCM66_A0788(acs-2)
VCI:	O3Y_17398
VCL:	VCLMA_B0605
VVU:	VV2_0456
VVY:	VVA1006
VVM:	VVMO6_03926
VPA:	VPA0575 VPA1158
VPB:	VPBB_A0525 VPBB_A1058
VHA:	VIBHAR_05420
VSP:	VS_II1510
VEX:	VEA_000409 VEA_001479
VEJ:	VEJY3_21806
VFU:	vfu_B00651
PPR:	PBPRB1168
VAN:	VAA_02976
PAE:	PA1997
PAU:	PA14_38690(acsA)
PAP:	PSPA7_3297
PAG:	PLES_33261
PAF:	PAM18_3048
PNC:	NCGM2_2971(acsA)
PDK:	PADK2_15665
PPU:	PP_3071
PPF:	Pput_2653
PPG:	PputGB1_2795
PPW:	PputW619_2720
PPT:	PPS_2627
PPB:	PPUBIRD1_2649
PPI:	YSA_10410
PPX:	T1E_2427(acsA2)
PPUH:	B479_12710
PPUU:	PputUW4_02372
PFL:	PFL_3577(acsA1)
PFO:	Pfl01_3080
PFS:	PFLU2627
PFE:	PSF113_3270
PFC:	PflA506_2396(acsA1)
PEN:	PSEEN3159
PMY:	Pmen_2028
PMK:	MDS_2693
PSC:	A458_06605
PBA:	PSEBR_a1970
PFV:	Psefu_2450
PDR:	H681_11415
ILO:	IL0879
SDE:	Sde_0006
MAQ:	Maqu_0089
MHC:	MARHY0077
MAD:	HP15_3799 HP15_4177
MBS:	MRBBS_0105(acsA1)
GAG:	Glaag_3572
TTU:	TERTU_0022
CBU:	CBU_0766
CBS:	COXBURSA331_A1185
CBD:	CBUD_0779
CBG:	CbuG_1236
CBC:	CbuK_0626
LPN:	lpg1831
LPU:	LPE509_01356
LPF:	lpl1795
LPP:	lpp1794
LPC:	LPC_1275(acsA)
LPA:	lpa_02645(acs)
LPE:	lp12_1770
LLO:	LLO_1072(acsA)
NOC:	Noc_2047
NHL:	Nhal_2509
AEH:	Mlg_2108
HCH:	HCH_03948
CSA:	Csal_1820
HEL:	HELO_2535(aacs)
ABO:	ABO_1236(acsA)
ADI:	B5T_00703 B5T_01987 B5T_02443(acsA)
MMW:	Mmwyl1_4181
AHA:	AHA_0140
ASA:	ASA_4249(acsA)
AVR:	B565_3933
OCE:	GU3_14895
CVI:	CV_1758
LHK:	LHK_02059
PSE:	NH8B_0039 NH8B_1995 NH8B_2945
RSL:	RPSI07_2633
RPI:	Rpic_0655
RPF:	Rpic12D_0699
REU:	Reut_A0764
REH:	H16_A2860(h16_A2860)
RME:	Rmet_2699(acsA)
CTI:	RALTA_A2344 RALTA_B0309
CNC:	CNE_1c27590(acsA4) CNE_BB1p08520(acsA3)
BPR:	GBP346_A0988
BUR:	Bcep18194_B1209
BCT:	GEM_3544
BPH:	Bphy_7003
BPY:	Bphyt_4720
BUG:	BC1001_4468
BYI:	BYI23_D001940
BPX:	BUPH_01032
RFR:	Rfer_3963
POL:	Bpro_0120
PNA:	Pnap_2133
AAV:	Aave_0119
AJS:	Ajs_0054
DIA:	Dtpsy_0074
AAA:	Acav_0152
ACK:	C380_00770
VEI:	Veis_3179
DAC:	Daci_0087 Daci_2270
DEL:	DelCs14_0086
VAP:	Vapar_0107
VPE:	Varpa_0122
CTT:	CtCNB1_0087 CtCNB1_1217
ADN:	Alide_0089
ADK:	Alide2_0080
RTA:	Rta_00980
TIN:	Tint_1662
THI:	THI_2082(acsA1)
EBA:	ebA321(acsA) ebA4666 ebA5760
AZO:	azo2149(acsA)
AZA:	AZKH_2691(acsA) AZKH_3280
DAR:	Daro_0177
TMZ:	Tmz1t_1658
DSU:	Dsui_2297
APP:	CAP2UW1_2344
GEB:	GM18_2088
DOL:	Dole_1247 Dole_1610
DAL:	Dalk_3789
DAT:	HRM2_09950(aac)
DTO:	TOL2_C06740(acsA2)
HOH:	Hoch_3889
DTI:	Desti_2897 Desti_5415
DBR:	Deba_0465
PEL:	SAR11G3_01104
MLO:	mlr6539
MCI:	Mesci_2424
MOP:	Mesop_2558
MAM:	Mesau_02451
MES:	Meso_0168
PLA:	Plav_0554 Plav_1154
SME:	SMc00774(acsA2)
SMK:	Sinme_0422
SMQ:	SinmeB_0327
SMX:	SM11_chr0366(acsA2)
SMI:	BN406_00344(acsA1)
SMEG:	C770_GR4Chr0708
SMEL:	SM2011_c00774(acsA2)
SMD:	Smed_0315
RHI:	NGR_c03330(acsA)
SFH:	SFHH103_00379(acsa1)
SFD:	USDA257_c03720(acsA1)
ATU:	Atu4130(acsA)
ARA:	Arad_0962
AGR:	AGROH133_12988
RET:	RHE_CH00719(acsA1)
REC:	RHECIAT_CH0000803(acsA1)
RLE:	RL0768(acsA)
RLT:	Rleg2_0380
RLG:	Rleg_0412
RTR:	RTCIAT899_CH03590
BME:	BMEI1921 BMEI1922
BMZ:	BM28_A0021 BM28_A0022
BMG:	BM590_A0021 BM590_A0022
BMW:	BMNI_I0020 BMNI_I0021
BMC:	BAbS19_I00180
BAA:	BAA13334_I00442
BMS:	BR0021
BSI:	BS1330_I0021
BSV:	BSVBI22_A0021
BOV:	BOV_0018
BCS:	BCAN_A0021
BSK:	BCA52141_I1664
BMR:	BMI_I21
BPP:	BPI_I21
OAN:	Oant_0036
BJA:	bll4282 blr4674
BJU:	BJ6T_50610
BRS:	S23_34840
AOL:	S58_60660
AZC:	AZC_2243
SNO:	Snov_0599
RVA:	Rvan_0111
PHL:	KKY_2316
SIL:	SPO1959
SIT:	TM1040_3294
SCH:	Sphch_3998
RRU:	Rru_A3695
RRF:	F11_18900
RPM:	RSPPHO_01067
MAG:	amb0580
AZL:	AZL_015680(acsA)
ALI:	AZOLI_1278
ABS:	AZOBR_p140024(acsA)
TMO:	TMO_1253
PBR:	PB2503_07454
APB:	SAR116_0685
MAI:	MICA_234
MAN:	A11S_228
APC:	HIMB59_00002750
BCK:	BCO26_0882
BAG:	Bcoa_0296
OIH:	OB0504
GKA:	GK1485
GTN:	GTNG_1330
GTH:	Geoth_1637
GTE:	GTCCBUS3UF5_17130
GWC:	GWCH70_1970
GYC:	GYMC61_2277
GYA:	GYMC52_1405
GCT:	GC56T3_2076
GMC:	GY4MC1_1555
GGH:	GHH_c14630(acsA1)
AFL:	Aflv_1278(acsA)
BTS:	Btus_1007 Btus_1122
DKU:	Desku_0178
DAI:	Desaci_1858
TMR:	Tmar_2008
MSM:	MSMEG_6024
MSG:	MSMEI_5865
MSA:	Mycsm_05831
MVA:	Mvan_5298
MGI:	Mflv_1473 Mflv_3863
MSP:	Mspyr1_32060 Mspyr1_46940
MAB:	MAB_4376c
MMC:	Mmcs_4700
MKM:	Mkms_4786
MJL:	Mjls_5085
MRH:	MycrhN_2255
MCB:	Mycch_4665
ASD:	AS9A_4348
CGT:	cgR_2955
CHN:	A605_00690
NFA:	nfa28650 nfa50420
NCY:	NOCYR_4825
NBR:	O3I_037990
RHA:	RHA1_ro00539 RHA1_ro06100
ROP:	ROP_32950(acsA) ROP_46180(acsA) ROP_61570(acsA)
REQ:	REQ_35990
GBR:	Gbro_1363
GPO:	GPOL_c12020
GOR:	KTR9_1277
TPR:	Tpau_3315
SCO:	SCO1393(acsA)
SMA:	SAV_562(acsA3) SAV_6970(acsA2)
SGR:	SGR_6136
SCB:	SCAB_76181(acsA) SCAB_90681
SSX:	SACTE_0815
SVL:	Strvi_5698
SCT:	SCAT_0729(acsA)
SCY:	SCATT_07310
SFA:	Sfla_5475
SBH:	SBI_01989
SHY:	SHJG_1240 SHJG_2810
SHO:	SHJGH_1075 SHJGH_2574
SVE:	SVEN_0982
SDV:	BN159_7201(acsA1)
SALB:	XNR_5448
STRP:	F750_1139
KSK:	KSE_15420
KRH:	KRH_18620(acsA)
TFU:	Tfu_2245
NDA:	Ndas_3253
NAL:	B005_0209
TCU:	Tcur_4014
SRO:	Sros_1444
FRA:	Francci3_3504
FRE:	Franean1_1238
FRI:	FraEuI1c_1164 FraEuI1c_2568
FAL:	FRAAL5696(acsA)
FSY:	FsymDg_3595
ACE:	Acel_1714
NML:	Namu_0304 Namu_2019
GOB:	Gobs_4892
BSD:	BLASA_1288(acsA2) BLASA_4751(acsA1)
MMAR:	MODMU_0416 MODMU_5288(acsA)
SEN:	SACE_0219(acsA)
SVI:	Svir_01880
TBI:	Tbis_0788
AMD:	AMED_0274(acsA) AMED_3268(acsA)
AMN:	RAM_01385 RAM_16625
AMM:	AMES_0269(acsA) AMES_3232(acsA)
PDX:	Psed_0236 Psed_4605
AMI:	Amir_0152
SESP:	BN6_01910(acsA1)
STP:	Strop_0937
SAQ:	Sare_0879
MAU:	Micau_0944
MIL:	ML5_1192
VMA:	VAB18032_09430
AMS:	AMIS_8480
CAI:	Caci_2192
SNA:	Snas_6018
RXY:	Rxyl_1569 Rxyl_2342
CWO:	Cwoe_4482
AFO:	Afer_1149
AYM:	YM304_13080
LIL:	LA_1173(acs)
LIE:	LIF_A0949(acs)
LIC:	LIC12516
LBI:	LEPBI_I3095(acsA1)
LBF:	LBF_2986
HHY:	Halhy_4161
DFE:	Dfer_3920
SLI:	Slin_4421
LBY:	Lbys_2963
FAE:	FAES_2487
GAU:	GAU_2126(acsA)
CYC:	PCC7424_4886
CYJ:	Cyan7822_2625
IAL:	IALB_1669(acsA)
RRS:	RoseRS_1953
RCA:	Rcas_3829
CAU:	Caur_3394
CAG:	Cagg_0246
CHL:	Chy400_3658
TRA:	Trad_0614
AFU:	AF0197(acs-1)
PTO:	PTO1175
VDI:	Vdis_2419
VMO:	VMUT_0761

Taxonomy

Reference

1 [PMID:7140777]

Authors

Fukui T, Ito M, Tomita K.

Title

Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M.

Journal

Eur. J. Biochem. 127 (1982) 423-8.

Organism

Zoogloea ramigera

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

39394-62-2

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (7)   
   KEGG REACTION (1)   
   KEGG RPAIR (4)   
   KEGG RCLASS (2)   
Gene (600)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (468)   
   KEGG DGENES (5)   
   KEGG EGENES (21)   
   KEGG MGENES (105)   
Protein sequence (1066)   
   UniProt (502)   
   PRF (20)   
   RefSeq(pep) (544)   
DNA sequence (856)   
   RefSeq(nuc) (540)   
   GenBank (156)   
   EMBL (160)   
Protein domain (1)   
   InterPro (1)   
Literature (1)   
   PubMed (1)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (2547)   

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