KEGG   ENZYME: 6.2.1.18Help
Entry
EC 6.2.1.18                 Enzyme                                 

Name
citrate---CoA ligase;
citryl-CoA synthetase;
citrate:CoA ligase;
citrate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
citrate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA [RN:R01322]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
(3S)-citryl-CoA [CPD:C00566]
Comment
The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.
History
EC 6.2.1.18 created 1986
Pathway
Carbon fixation pathways in prokaryotes
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K15232  
citryl-CoA synthetase large subunit
Genes
DKU: 
CWO: 
CTM: 
AAE: 
aq_1306(sucC1)
HYA: 
HTH: 
HTH_1737(ccsA)
TAL: 
Taxonomy
Reference
1  [PMID:6749502]
  Authors
Lill U, Schreil A, Eggerer H.
  Title
Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
  Journal
Eur. J. Biochem. 125 (1982) 645-50.
  Organism
Rattus norvegicus
Reference
2  [PMID:15101981]
  Authors
Aoshima M, Ishii M, Igarashi Y.
  Title
A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.
  Journal
Mol. Microbiol. 52 (2004) 751-61.
  Organism
Hydrogenobacter thermophilus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
856428-87-0

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