KEGG   ENZYME: 6.2.1.23Help
Entry
EC 6.2.1.23                 Enzyme                                 

Name
dicarboxylate---CoA ligase;
carboxylyl-CoA synthetase;
dicarboxylyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
omega-dicarboxylate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + an alpha,omega-dicarboxylate + CoA = AMP + diphosphate + an omega-carboxyacyl-CoA [RN:R04157]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
alpha,omega-dicarboxylate;
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
omega-carboxyacyl-CoA [CPD:C03188]
Comment
Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.
History
EC 6.2.1.23 created 1989, modified 2011
Reference
1  [PMID:4062873]
  Authors
Vamecq J, de Hoffmann E, Van Hoof F.
  Title
The microsomal dicarboxylyl-CoA synthetase.
  Journal
Biochem. J. 230 (1985) 683-93.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99332-77-1

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