KEGG   ENZYME: 6.2.1.25Help
Entry
EC 6.2.1.25                 Enzyme                                 

Name
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
benzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512]
Comment
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.
History
EC 6.2.1.25 created 1989
Pathway
Benzoate degradation
Aminobenzoate degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04105  
4-hydroxybenzoate-CoA ligase
K04110  
benzoate-CoA ligase
Genes
RPJ: 
REU: 
REH: 
H16_A1412(h16_A1412) H16_B1918
CNC: 
RME: 
Rmet_1224(bzdA)
CTI: 
BXE: 
BXB: 
DR64_3582(bclA) DR64_7554(bclA)
BPH: 
BPY: 
BGL: 
BUG: 
BGE: 
BGF: 
BRH: 
BPX: 
PPK: 
PPNO: 
PRB: 
BPT: 
BHO: 
D560_2016(bclA)
AXY: 
AXO: 
AXN: 
AKA: 
AMIM: 
CDN: 
RFR: 
POL: 
PNA: 
ACK: 
VEI: 
DAC: 
DEL: 
VAP: 
VPE: 
VPD: 
CTT: 
CTES: 
RTA: 
LCH: 
THI: 
THI_0472(badA)
EBA: 
ebA2757(bclA) ebA5301(bclA)
AZO: 
azo3052(bzdA)
AZA: 
AZKH_2151(bclA) AZKH_2927(hbcL) AZKH_4514(bclA)
TMZ: 
GME: 
Gmet_2143(bamY)
GLO: 
GEO: 
GEM: 
DMA: 
DAS: 
DPR: 
DTO: 
SCU: 
SAT: 
DTI: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
AOL: 
RPA: 
RPA0661(badA) RPA0669(hbaA)
RPB: 
RPC: 
RPD: 
RPE: 
RPT: 
RPX: 
RVA: 
SIL: 
SPO3697(badA-1)
JAN: 
SWI: 
RPM: 
MAG: 
GYC: 
GYA: 
GCT: 
GJF: 
DGI: 
SCB: 
SFI: 
BSD: 
AMD: 
AMED_8609(badA)
AMN: 
AMM: 
AMES_6861(badA) AMES_8478(badA)
AMZ: 
B737_6861(badA) B737_8479(badA)
AOI: 
AORI_1759(badA) AORI_7395(badA)
AJA: 
AMQ: 
PDX: 
RRD: 
GLP: 
MIC: 
 » show all
Taxonomy
Reference
1
  Authors
Hutber, G.N. and Ribbons, D.W.
  Title
Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris.
  Journal
J. Gen. Microbiol. 129 (1983) 2413-2420.
Reference
2  [PMID:2857161]
  Authors
Schennen U, Braun K, Knackmuss HJ.
  Title
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria.
  Journal
J. Bacteriol. 161 (1985) 321-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
95329-17-2

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