KEGG   ENZYME: 6.2.1.28Help
Entry
EC 6.2.1.28                 Enzyme                                 

Name
3alpha,7alpha-dihydroxy-5beta-cholestanate---CoA ligase;
3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase;
DHCA-CoA ligase;
3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA [RN:R04507]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate;
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
(25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA [CPD:C17345]
History
EC 6.2.1.28 created 1992
Reference
1  [PMID:3183523]
  Authors
Prydz K, Kase BF, Bjorkhem I, Pedersen JI.
  Title
Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver.
  Journal
J. Lipid. Res. 29 (1988) 997-1004.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
118732-03-9

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