KEGG   ENZYME: 6.2.1.36Help
Entry
EC 6.2.1.36                 Enzyme                                 

Name
3-hydroxypropionyl-CoA synthase;
3-hydroxypropionyl-CoA synthetase (AMP-forming);
3-hydroxypropionate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
hydroxypropionate:CoA ligase (AMP-forming)
Reaction(IUBMB)
3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate [RN:R09286]
Reaction(KEGG)
Substrate
3-hydroxypropionate [CPD:C01013];
ATP [CPD:C00002];
CoA [CPD:C00010]
Product
3-hydroxypropionyl-CoA [CPD:C05668];
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1,2].
The enzymes from Metallosphaera sedula and Sulfolobus tokodaii can also use propionate, acrylate, acetate, and butanoate as substrates [2], and are thus different from EC 6.2.1.17 (propionate---CoA ligase), which does not accept acetate or butanoate.
History
EC 6.2.1.36 created 2009
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15018  
3-hydroxypropionyl-coenzyme A synthetase
Genes
CTM: 
CTS: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
SSO: 
SSO3203(acsA-10)
SOL: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
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AHO: 
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
  Organism
Metallosphaera sedula
Reference
2  [PMID:18165310]
  Authors
Alber BE, Kung JW, Fuchs G
  Title
3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation.
  Journal
J. Bacteriol. 190 (2008) 1383-9.
  Organism
Metallosphaera sedula, Sulfolobus tokodaii
  Sequence
[mse:Msed_1456] [sto:ST0783]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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