KEGG   ENZYME: 6.2.1.37Help
Entry
EC 6.2.1.37                 Enzyme                                 

Name
3-hydroxybenzoate---CoA ligase;
3-hydroxybenzoyl-CoA synthetase;
3-hydroxybenzoate---coenzyme A ligase (AMP-forming);
3-hydroxybenzoyl coenzyme A synthetase;
3-hydroxybenzoyl-CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
3-hydroxybenzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA [RN:R09589]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
3-hydroxybenzoate [CPD:C00587];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
3-hydroxybenzoyl-CoA [CPD:C05195]
Comment
The enzyme works equally well with 4-hydroxybenzoate but shows low activity towards benzoate, 4-aminobenzoate, 3-aminobenzoate, 3-fluorobenzoate, 4-fluorobenzoate, 3-chlorobenzoate, and 4-chlorobenzoate. There is no activity with 3,4-dihydroxybenzoate, 2,3-dihydroxybenzoate, and 2-hydroxybenzoate as substrates.
History
EC 6.2.1.37 created 2011
Reference
1  [PMID:11208796]
  Authors
Laempe D, Jahn M, Breese K, Schagger H, Fuchs G
  Title
Anaerobic metabolism of 3-hydroxybenzoate by the denitrifying bacterium Thauera aromatica.
  Journal
J. Bacteriol. 183 (2001) 968-79.
  Organism
Thauera aromatica
  Sequence
[up:Q9AJS8]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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