KEGG   ENZYME: 6.2.1.40Help
Entry
EC 6.2.1.40                 Enzyme                                 

Name
4-hydroxybutyrate---CoA ligase;
4-hydroxybutyrate-CoA synthetase;
4-hydroxybutyrate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle.
History
EC 6.2.1.40 created 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14466  4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467  4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861  4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
AFU: AF_1287
AFG: AFULGI_00013960
APO: Arcpr_1040
GAC: GACE_0172
IHO: Igni_0475
PFM: Pyrfu_1031
SSO: SSO1595(alkK-1)
SOL: Ssol_2425
SSOA: SULA_2450
SSOL: SULB_2451
SSOF: SULC_2448
STO: STK_20950
SAI: Saci_2146
SID: M164_0543
SII: LD85_0554
SIH: SiH_0833
SIR: SiRe_0517
SIC: SiL_0542
PAI: PAE2474
PIS: Pisl_0250
PCL: Pcal_1386
POG: Pogu_1296
TNE: Tneu_0420
TUZ: TUZN_0914
TTN: TTX_1100(acsA)
 » show all
Taxonomy
Reference
1  [PMID:21169482]
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J. Bacteriol. 193 (2011) 1201-11.
  Sequence
[tne:Tneu_0420]
Reference
2  [PMID:23258541]
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J. Biol. Chem. 288 (2013) 4012-22.
  Sequence
[mse:Msed_0406]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.40
IUBMB Enzyme Nomenclature: 6.2.1.40
ExPASy - ENZYME nomenclature database: 6.2.1.40
BRENDA, the Enzyme Database: 6.2.1.40

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