KEGG   ENZYME: 6.2.1.40Help
Entry
EC 6.2.1.40                 Enzyme                                 

Name
4-hydroxybutyrate---CoA ligase;
4-hydroxybutyrate-CoA synthetase;
4-hydroxybutyrate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle.
History
EC 6.2.1.40 created 2014
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14466  
4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467  
4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861  
4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
AFU: 
AFG: 
APO: 
IHO: 
PFM: 
SSO: 
SSO1595(alkK-1)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PYR: 
POG: 
TNE: 
TUZ: 
TTN: 
TTX_1100(acsA)
 » show all
Taxonomy
Reference
1  [PMID:21169482]
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J. Bacteriol. 193 (2011) 1201-11.
  Sequence
[tne:Tneu_0420]
Reference
2  [PMID:23258541]
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J. Biol. Chem. 288 (2013) 4012-22.
  Sequence
[mse:Msed_0406]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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