KEGG   ENZYME: 6.2.1.6Help
Entry
EC 6.2.1.6                  Enzyme                                 

Name
glutarate---CoA ligase;
glutaryl-CoA synthetase;
glutaryl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
glutarate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA [RN:R02402]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
glutarate [CPD:C00489];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
glutaryl-CoA [CPD:C00527]
Comment
GTP or ITP can act instead of ATP.
History
EC 6.2.1.6 created 1961
Pathway
Fatty acid degradation
Lysine degradation
Reference
1  [PMID:13769477]
  Authors
MENON GK, FRIEDMAN DL, STERN JR.
  Title
Enzymic synthesis of glutaryl-coenzyme A.
  Journal
Biochim. Biophys. Acta. 44 (1960) 375-7.
  Organism
Canis familiaris, Rattus norvegicus, pigeon
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-68-1

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