KEGG   ENZYME: 6.3.1.17Help
Entry
EC 6.3.1.17                 Enzyme                                 

Name
beta-citrylglutamate synthase;
NAAG synthetase I;
NAAGS-I;
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
citrate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate [RN:R10677]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
citrate [CPD:C00158];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
beta-citryl-L-glutamate [CPD:C20775]
Comment
The enzyme, found in animals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.1.17 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase
Genes
HSA: 57494(RIMKLB)
PTR: 735860(RIMKLB)
PPS: 100974820(RIMKLB)
GGO: 101136567(RIMKLB)
PON: 100441104(RIMKLB)
NLE: 100593570(RIMKLB)
MCC: 722261(RIMKLB)
MCF: 102124154(RIMKLB)
CSAB: 103218536(RIMKLB)
RRO: 104672842(RIMKLB)
RBB: 108543684(RIMKLB)
CJC: 100406491(RIMKLB)
SBQ: 101033047(RIMKLB)
MMU: 108653(Rimklb)
RNO: 362428(Rimklb)
CGE: 100760031(Rimklb)
NGI: 103727467(Rimklb)
HGL: 101706744(Rimklb)
CCAN: 109697724(Rimklb)
OCU: 100346793(RIMKLB)
TUP: 102472940(RIMKLB)
CFA: 486698(RIMKLB)
AML: 100473320(RIMKLB)
UMR: 103669163(RIMKLB)
ORO: 101374535(RIMKLB)
FCA: 101097740(RIMKLB)
PTG: 102963865(RIMKLB)
AJU: 106965320(RIMKLB)
BTA: 538579(RIMKLB)
BOM: 102269649(RIMKLB)
BIU: 109559695(RIMKLB)
PHD: 102321435(RIMKLB)
CHX: 102176861(RIMKLB)
OAS: 101102554(RIMKLB)
SSC: 100152915(RIMKLB)
CFR: 102503881(RIMKLB)
CDK: 105098170(RIMKLB)
BACU: 103019013(RIMKLB)
LVE: 103069710(RIMKLB)
OOR: 101273054(RIMKLB)
ECB: 100061350(RIMKLB)
EPZ: 103564581(RIMKLB)
EAI: 106837431(RIMKLB)
MYB: 102245342(RIMKLB)
MYD: 102752373(RIMKLB)
HAI: 109372752(RIMKLB)
RSS: 109435559(RIMKLB)
PALE: 102880426(RIMKLB)
LAV: 100657534(RIMKLB)
TMU: 101361972
MDO: 100013787(RIMKLB)
SHR: 100930894(RIMKLB)
OAA: 100080568(RIMKLB) 100090307
GGA: 418255(RIMKLB)
MGP: 104916636
CJO: 107318392(RIMKLB)
APLA: 101792875(RIMKLB)
ACYG: 106048091(RIMKLB)
TGU: 100220208(RIMKLB)
GFR: 102035986(RIMKLB)
FAB: 101814507(RIMKLB)
PHI: 102111957(RIMKLB)
PMAJ: 107210434(RIMKLB)
CCW: 104690266(RIMKLB)
FPG: 101913481(RIMKLB)
FCH: 102056126(RIMKLB)
CLV: 102098362(RIMKLB)
EGZ: 104122771(RIMKLB)
AAM: 106495722(RIMKLB)
ASN: 102373845(RIMKLB)
AMJ: 102576775(RIMKLB)
PSS: 102451018(RIMKLB)
CMY: 102933090(RIMKLB)
CPIC: 101943668(RIMKLB)
ACS: 100563778(rimklb)
PVT: 110069781(RIMKLB)
PBI: 103055545(RIMKLB)
GJA: 107117747(RIMKLB)
XTR: 100486701(rimklb)
NPR: 108799485(RIMKLB)
DRE: 447815(rimkla)
SANH: 107669631
IPU: 108265850(rimkla)
AMEX: 103035057
TRU: 101062827
LCO: 104920219(rimkla)
NCC: 104955181(rimkla)
MZE: 101477475
OLA: 101169452(rimklb)
XMA: 102218635
PRET: 103467997(rimkla)
NFU: 107390714
CSEM: 103384935
LCF: 108891717(rimkla)
BPEC: 110161111
ELS: 105013808
LCM: 102351441(RIMKLB) 102354509(RIMKLA)
CMK: 103190080(rimkla)
SALU: DC74_1330
SALL: SAZ_07145
STRE: GZL_07873
SLD: T261_0304
SRW: TUE45_pSRc_0607(rimK)
SNR: SNOUR_35955(rimKLB)
SALF: SMD44_08847(cofF)
SALJ: SMD11_0857
 » show all
Taxonomy
Reference
1  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J. Biol. Chem. 285 (2010) 29826-33.
  Sequence
[mmu:108653]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.1.17
IUBMB Enzyme Nomenclature: 6.3.1.17
ExPASy - ENZYME nomenclature database: 6.3.1.17
BRENDA, the Enzyme Database: 6.3.1.17

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