KEGG   ENZYME: 6.3.1.18Help
Entry
EC 6.3.1.18                 Enzyme                                 

Name
gamma-glutamylanilide synthase;
atdA1 (gene name);
tdnQ (gene name);
dcaQ (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
L-glutamate:aniline ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine [RN:R10772]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
aniline [CPD:C00292]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N5-phenyl-L-glutamine [CPD:C20843]
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.
History
EC 6.3.1.18 created 2014
Orthology
K20419  
gamma-glutamylanilide synthase
Reference
1  [PMID:23893114]
  Authors
Takeo M, Ohara A, Sakae S, Okamoto Y, Kitamura C, Kato D, Negoro S
  Title
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide.
  Journal
J. Bacteriol. 195 (2013) 4406-14.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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