KEGG   ENZYME: 6.3.1.9Help
Entry
EC 6.3.1.9                  Enzyme                                 

Name
trypanothione synthase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
glutathionylspermidine:glutathione ligase (ADP-forming)
Reaction(IUBMB)
glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate [RN:R03822]
Reaction(KEGG)
Substrate
glutathione [CPD:C00051];
glutathionylspermidine [CPD:C05730];
ATP [CPD:C00002]
Product
N1,N8-bis(glutathionyl)spermidine [CPD:C02090];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Involved in the synthesis of trypanothione in trypanosomatids
History
EC 6.3.1.9 created 1999
Pathway
Glutathione metabolism
Metabolic pathways
Orthology
K01833  
trypanothione synthetase/amidase
Genes
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
Taxonomy
Reference
1  [PMID:1304372]
  Authors
Smith K, Nadeau K, Bradley M, Walsh C, Fairlamb AH.
  Title
Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata.
  Journal
Protein. Sci. 1 (1992) 874-83.
  Organism
Crithidia fasciculata
  Sequence
[up:O60993]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
130246-69-4

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