Entry
Name
gamma-glutamylhistamine synthase;
gamma-glutaminylhistamine synthetase;
gamma-GHA synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
L-glutamate:histamine ligase
Reaction(IUBMB)
ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine [RN:
R07643 ]
Reaction(KEGG)
Substrate
Product
products of ATP breakdown [CPD:
C07305 ];
Nalpha-gamma-L-glutamylhistamine [CPD:
C04138 ]
History
EC 6.3.2.18 created 1986
Reference
Authors
Stein C, Weinreich D.
Title
An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.18
ExPASy - ENZYME nomenclature database: 6.3.2.18