KEGG   ENZYME: 6.3.2.18Help
Entry
EC 6.3.2.18                 Enzyme                                 

Name
gamma-glutamylhistamine synthase;
gamma-glutaminylhistamine synthetase;
gamma-GHA synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
L-glutamate:histamine ligase
Reaction(IUBMB)
ATP + L-glutamate + histamine = products of ATP breakdown + Nalpha-gamma-L-glutamylhistamine [RN:R07643]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
histamine [CPD:C00388]
Product
products of ATP breakdown [CPD:C07305];
Nalpha-gamma-L-glutamylhistamine [CPD:C04138]
History
EC 6.3.2.18 created 1986
Reference
1  [PMID:6125565]
  Authors
Stein C, Weinreich D.
  Title
An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica.
  Journal
J. Neurochem. 38 (1982) 204-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82904-08-3

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