KEGG   ENZYME: 6.3.2.21Help
Entry
EC 6.3.2.21                 Enzyme                                 
Name
ubiquitin---calmodulin ligase;
ubiquityl-calmodulin synthase;
ubiquitin-calmodulin synthetase;
ubiquityl-calmodulin synthetase;
uCaM-synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
calmodulin:ubiquitin ligase (AMP-forming)
Reaction(IUBMB)
n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + (ubiquitin)n-calmodulin [RN:R05193]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
calmodulin [CPD:C00391];
ubiquitin [CPD:C00496]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
(ubiquitin)n-calmodulin [CPD:C03330]
Comment
Specific for Ca2+-calmodulin from vertebrates. At least three ubiquitin molecules can be coupled to lysine residues in calmodulin.
Reference
1  [PMID:2853950]
  Authors
Jennissen HP, Laub M.
  Title
Ubiquitin-calmodulin conjugating activity from cardiac muscle.
  Journal
Biol. Chem. Hoppe. Seyler. 369 (1988) 1325-30.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:2853949]
  Authors
Ziegenhagen R, Jennissen HP.
  Title
Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase.
  Journal
Biol. Chem. Hoppe. Seyler. 369 (1988) 1317-24.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
119632-60-9
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