KEGG   ENZYME: 6.3.2.24Help
Entry
EC 6.3.2.24                 Enzyme                                 

Name
tyrosine---arginine ligase;
tyrosyl-arginine synthase;
kyotorphin synthase;
kyotorphin-synthesizing enzyme;
kyotorphin synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
L-tyrosine:L-arginine ligase (AMP-forming)
Reaction(IUBMB)
ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine [RN:R00735]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-tyrosine [CPD:C00082];
L-arginine [CPD:C00062]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-tyrosyl-L-arginine [CPD:C02993]
History
EC 6.3.2.24 created 1992
Reference
1  [PMID:3597366]
  Authors
Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H.
  Title
Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes.
  Journal
J. Biol. Chem. 262 (1987) 8165-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116036-78-3

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