Entry
Name
tetrahydrosarcinapterin synthase;
H4MPT:alpha-L-glutamate ligase;
MJ0620;
MptN protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin [RN:
R09594 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].
History
EC 6.3.2.33 created 2010
Pathway
Orthology
K15740 tetrahydromethanopterin:alpha-L-glutamate ligase
Genes
BUE : BRPE67_BCDS01440(rimK)
PTER : C2L65_26160 C2L65_34285
BUO : BRPE64_BCDS01580(rimK)
MAQU : Maq22A_c16480(rimK)
ALI : AZOLI_p10699 AZOLI_p10888
AZS : E6C72_18240 E6C72_22390
MFF : MFFC18_17590(rimK_2)
LCRE : Pla8534_62270(rimK_3)
GPN : Pan110_11870(rimK_1)
PLON : Pla110_18950(rimK_2)
LOKI : Lokiarch_28770(mptN)
» show all
Taxonomy
Reference
Authors
Li H, Xu H, Graham DE, White RH
Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.33
ExPASy - ENZYME nomenclature database: 6.3.2.33