KEGG   ENZYME: 6.3.2.33Help
Entry
EC 6.3.2.33                 Enzyme                                 

Name
tetrahydrosarcinapterin synthase;
H4MPT:alpha-L-glutamate ligase;
MJ0620;
MptN protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin [RN:R09594]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
tetrahydromethanopterin [CPD:C01217];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5,6,7,8-tetrahydrosarcinapterin [CPD:C18802]
Comment
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].
History
EC 6.3.2.33 created 2010
Pathway
Folate biosynthesis
Orthology
K15740  
tetrahydromethanopterin:alpha-L-glutamate ligase
Genes
BACW: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_3268(rimK)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
Mbur_1276(mptN)
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_0555(mptN)
MHI: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:12909715]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9785-90.
  Sequence
[mja:MJ_0620]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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