KEGG   ENZYME: 6.3.2.39Help
Entry
EC 6.3.2.39                 Enzyme                                 

Name
aerobactin synthase;
iucC (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
N2-citryl-N6-acetyl-N6-hydroxy-L-lysine:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)
Reaction(IUBMB)
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + aerobactin [RN:R10091]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N2-citryl-N6-acetyl-N6-hydroxy-L-lysine [CPD:C20333];
N6-acetyl-N6-hydroxy-L-lysine [CPD:C03955];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
aerobactin [CPD:C05554]
Comment
Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation [6]. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate [3,4,5].
History
EC 6.3.2.39 created 2012
Pathway
Lysine degradation
Microbial metabolism in diverse environments
Orthology
K03895  
aerobactin synthase
Genes
EOJ: 
EOI: 
ECC: 
c3625(iucC)
ECV: 
ECM: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_3448(iucC)
EUM: 
ECZ: 
ELN: 
ESO: 
ESM: 
ESL: 
EAB: 
ENA: 
ELC: 
i14_3318(iucC)
ELD: 
i02_3318(iucC)
ECOJ: 
ECOO: 
ECOH: 
SEM: 
SES: 
YPE: 
YPO0992(iucC)
YPK: 
y3383(iucC)
YPA: 
YPN: 
YPM: 
YP_3448(iucC)
YPP: 
YPG: 
YPZ: 
YPZ3_0746(iucC)
YPT: 
YPD: 
YPD4_0701(iucC)
YPX: 
YPD8_0701(iucC)
YPH: 
YPC_0800(iucC)
YPS: 
YPTB3265(iucC)
YPI: 
YPY: 
YPB: 
YPQ: 
YSI: 
SFL: 
SF3717(iucC)
SFX: 
S4054(iucC)
SFV: 
SFV_3852(iucC)
SFE: 
SFN: 
SFS: 
SSN: 
SSON_3603(iucC)
SSJ: 
SBO: 
SBO_4339(iucC)
SBC: 
PWA: 
PEC: 
ENC: 
ECL_03318(iucC)
ENO: 
EEC: 
ENL: 
ECLA: 
ECLC: 
EAU: 
ESA: 
CSZ: 
CSI: 
CTU: 
KPU: 
KPO: 
KPR: 
KPR_4895(iucC)
CKO: 
SPE: 
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
SMAF: 
SLQ: 
PAM: 
PANA_0352(iucC)
PLF: 
PAJ: 
PAJ_3507(iucC)
PAQ: 
CNT: 
CEM: 
CEN: 
VFI: 
VF_A0163(iucC)
VFM: 
SWD: 
NOC: 
NWA: 
KKO: 
BBA: 
Bd1574(iucC)
BBAT: 
Bdt_1567(iucC)
BBAC: 
BMX: 
BMS_0526(iucC)
OAN: 
OAH: 
MET: 
GBE: 
GBH: 
GBC: 
GBS: 
SAO: 
FRA: 
 » show all
Taxonomy
Reference
1
  Authors
Appanna, D.L., Grundy, B.J., Szczepan, E.W. and Viswanatha, T.
  Title
Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1.
  Journal
Biochim. Biophys. Acta 801 (1984) 437-443.
Reference
2  [PMID:4313071]
  Authors
Gibson F, Magrath DI.
  Title
The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I.
  Journal
Biochim. Biophys. Acta. 192 (1969) 175-84.
Reference
3
  Authors
Maurer, P.J. and Miller, M.
  Title
Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine.
  Journal
J. Am. Chem. Soc. 104 (1982) 3096-3101.
Reference
4  [PMID:2935523]
  Authors
de Lorenzo V, Bindereif A, Paw BH, Neilands JB.
  Title
Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12.
  Journal
J. Bacteriol. 165 (1986) 570-8.
  Sequence
[up:Q47318]
Reference
5  [PMID:3087960]
  Authors
de Lorenzo V, Neilands JB
  Title
Characterization of iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli.
  Journal
J. Bacteriol. 167 (1986) 350-5.
  Sequence
[up:Q47318]
Reference
6  [PMID:15719346]
  Authors
Challis GL.
  Title
A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases.
  Journal
Chembiochem. 6 (2005) 601-11.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system