KEGG   ENZYME: 6.3.2.40Help
Entry
EC 6.3.2.40                 Enzyme                                 

Name
cyclopeptine synthase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine forming)
Reaction(IUBMB)
2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine [RN:R10495]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
S-adenosyl-L-methionine [CPD:C00019];
anthranilate [CPD:C00108];
L-phenylalanine [CPD:C00079]
Product
cyclopeptine [CPD:C20579];
AMP [CPD:C00020];
diphosphate [CPD:C00013];
S-adenosyl-L-homocysteine [CPD:C00021]
Comment
Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in the fungus Penicillium cyclopium. The enzyme is a non-ribosomal peptide synthase.
History
EC 6.3.2.40 created 2013
Reference
1  [PMID:2995633]
  Authors
Lerbs W, Luckner M.
  Title
Cyclopeptine synthetase activity in surface cultures of Penicillium cyclopium.
  Journal
J. Basic. Microbiol. 25 (1985) 387-91.
Reference
2
  Authors
Gerlach, M, Schwelle, N., Lerbs, W. and Luckner, M.
  Title
Enzymatic synthesis of cyclopeptine intermediates in Penicillium cyclopium.
  Journal
Phytochemistry 24 (1985) 1935-1939.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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