KEGG   ENZYME: 6.3.2.41Help
Entry
EC 6.3.2.41                 Enzyme                                 

Name
N-acetylaspartylglutamate synthase;
N-acetylaspartylglutamate synthetase;
NAAG synthetase;
NAAGS;
RIMKLA (gene name) (ambiguous);
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)
Reaction(IUBMB)
ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate [RN:R10678]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamate [CPD:C12270]
Comment
The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].
History
EC 6.3.2.41 created 2014
Pathway
Alanine, aspartate and glutamate metabolism
Metabolic pathways
Orthology
K18310  
beta-citrylglutamate/N-acetylaspartylglutamate synthase
K18311  
N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA: 
284716(RIMKLA) 57494(RIMKLB)
PTR: 
735860(RIMKLB) 748944(RIMKLA)
PPS: 
100970527(RIMKLA) 100974820(RIMKLB)
GGO: 
101136567(RIMKLB) 101137769(RIMKLA)
PON: 
100441104(RIMKLB) 100457877(RIMKLA)
NLE: 
100589997(RIMKLA) 100593570(RIMKLB)
MCC: 
699767(RIMKLA) 722261(RIMKLB)
MCF: 
102124154(RIMKLB) 102128755(RIMKLA)
CSAB: 
103218536(RIMKLB) 103225007(RIMKLA)
RRO: 
104668996(RIMKLA) 104672842(RIMKLB)
CJC: 
100400904(RIMKLA) 100406491(RIMKLB)
SBQ: 
101028223(RIMKLA) 101033047(RIMKLB)
MMU: 
108653(Rimklb) 194237(Rimkla)
RNO: 
362428(Rimklb)
CGE: 
100759423(Rimkla) 100760031(Rimklb)
NGI: 
103727467(Rimklb) 103735994(Rimkla)
HGL: 
101706744(Rimklb) 101721728(Rimkla)
OCU: 
100346793(RIMKLB) 100356205(RIMKLA)
TUP: 
102472940(RIMKLB) 102474653(RIMKLA)
CFA: 
482445(RIMKLA) 486698(RIMKLB)
AML: 
100472546(RIMKLA) 100473320(RIMKLB)
UMR: 
103669163(RIMKLB) 103670923(RIMKLA)
FCA: 
101097740(RIMKLB) 101099388(RIMKLA)
PTG: 
102959348(RIMKLA) 102963865(RIMKLB)
BTA: 
507323(RIMKLA) 538579(RIMKLB)
BOM: 
102269649(RIMKLB) 102285876(RIMKLA)
PHD: 
102321435(RIMKLB) 102329993(RIMKLA)
CHX: 
102176861(RIMKLB) 102179728(RIMKLA)
OAS: 
101102554(RIMKLB) 101104941(RIMKLA)
SSC: 
100152915(RIMKLB) 100522878(RIMKLA)
CFR: 
102503881(RIMKLB) 102522941(RIMKLA)
BACU: 
103018606(RIMKLA) 103019013(RIMKLB)
LVE: 
103069710(RIMKLB) 103083571(RIMKLA)
ECB: 
100061350(RIMKLB) 100067475(RIMKLA)
MYB: 
102245342(RIMKLB) 102249129(RIMKLA)
MYD: 
102752373(RIMKLB) 102754710(RIMKLA)
PALE: 
102880426(RIMKLB) 102882758(RIMKLA)
LAV: 
100657534(RIMKLB) 100664484(RIMKLA)
MDO: 
100013787(RIMKLB) 100026482(RIMKLA)
SHR: 
100913508(RIMKLA) 100930894(RIMKLB)
OAA: 
100073839(RIMKLA) 100080568(RIMKLB) 100090307
GGA: 
418255(RIMKLB)
MGP: 
CJO: 
107318392(RIMKLB)
APLA: 
101792875(RIMKLB)
TGU: 
100220208(RIMKLB)
GFR: 
102035986(RIMKLB)
FAB: 
101814507(RIMKLB)
PHI: 
102111957(RIMKLB)
CCW: 
104690266(RIMKLB)
FPG: 
101913481(RIMKLB)
FCH: 
102056126(RIMKLB)
CLV: 
102098362(RIMKLB)
AAM: 
106495722(RIMKLB)
ASN: 
102373845(RIMKLB)
AMJ: 
102576775(RIMKLB)
PSS: 
102451018(RIMKLB)
CMY: 
102933090(RIMKLB)
ACS: 
100563778(rimklb)
PBI: 
103055545(RIMKLB)
GJA: 
107117747(RIMKLB)
XTR: 
100145548(rimkla) 100486701(rimklb)
DRE: 
447815(rimkla)
TRU: 
TNG: 
MZE: 
OLA: 
101169452(rimkla)
XMA: 
SASA: 
LCM: 
102351441(RIMKLB) 102354509(RIMKLA)
CMK: 
103190080(rimkla)
SALU: 
SALL: 
STRE: 
SLD: 
SRW: 
 » show all
Taxonomy
Reference
1  [PMID:20643647]
  Authors
Becker I, Lodder J, Gieselmann V, Eckhardt M
  Title
Molecular characterization of N-acetylaspartylglutamate synthetase.
  Journal
J. Biol. Chem. 285 (2010) 29156-64.
  Sequence
[mmu:108653] [hsa:57494]
Reference
2  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J. Biol. Chem. 285 (2010) 29826-33.
  Sequence
Reference
3  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J. Biol. Chem. 286 (2011) 16693-706.
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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