KEGG   ENZYME: 6.3.2.42Help
Entry
EC 6.3.2.42                 Enzyme                                 

Name
N-acetylaspartylglutamylglutamate synthase;
N-acetylaspartylglutamylglutamate synthetase;
NAAG(2) synthase;
NAAG synthetase II;
NAAGS-II;
RIMKLA (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamyl-L-glutamate-forming)
Reaction(IUBMB)
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [RN:R10679]
Reaction(KEGG)
R10679;
(other) R10678 R10693
Show
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamyl-L-glutamate [CPD:C20776]
Comment
The enzyme, found in mammals, also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase.
History
EC 6.3.2.42 created 2014
Pathway
Alanine, aspartate and glutamate metabolism
Metabolic pathways
Orthology
K18311  
N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA: 
284716(RIMKLA)
PTR: 
748944(RIMKLA)
PPS: 
100970527(RIMKLA)
GGO: 
101137769(RIMKLA)
PON: 
100457877(RIMKLA)
NLE: 
100589997(RIMKLA)
MCC: 
699767(RIMKLA)
MCF: 
102128755(RIMKLA)
RRO: 
104668996(RIMKLA)
CJC: 
100400904(RIMKLA)
MMU: 
194237(Rimkla)
CGE: 
100759423(Rimkla)
NGI: 
103735994(Rimkla)
HGL: 
101721728(Rimkla)
OCU: 
100356205(RIMKLA)
TUP: 
102474653(RIMKLA)
CFA: 
482445(RIMKLA)
AML: 
100472546(RIMKLA)
UMR: 
103670923(RIMKLA)
FCA: 
101099388(RIMKLA)
PTG: 
102959348(RIMKLA)
BTA: 
507323(RIMKLA)
BOM: 
102285876(RIMKLA)
PHD: 
102329993(RIMKLA)
CHX: 
102179728(RIMKLA)
OAS: 
101104941(RIMKLA)
SSC: 
100522878(RIMKLA)
CFR: 
102522941(RIMKLA)
BACU: 
103018606(RIMKLA)
LVE: 
103083571(RIMKLA)
ECB: 
100067475(RIMKLA)
MYB: 
102249129(RIMKLA)
MYD: 
102754710(RIMKLA)
PALE: 
102882758(RIMKLA)
MDO: 
100026482(RIMKLA)
SHR: 
100913508(RIMKLA)
OAA: 
100073839(RIMKLA)
 » show all
Taxonomy
Reference
1  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J. Biol. Chem. 286 (2011) 16693-706.
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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