KEGG   ENZYME: 6.3.2.46Help
Entry
EC 6.3.2.46                 Enzyme                                 

Name
fumarate---(S)-2,3-diaminopropanoate ligase;
DdaG
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
fumarate:(S)-2,3-diaminopropanoate ligase (AMP-forming)
Reaction(IUBMB)
ATP + fumarate + (S)-2,3-diaminopropanoate = AMP + diphosphate + N3-fumaroyl-(S)-2,3-diaminopropanoate [RN:R10940]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
fumarate [CPD:C00122];
(S)-2,3-diaminopropanoate [CPD:C03401]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
N3-fumaroyl-(S)-2,3-diaminopropanoate [CPD:C20961]
Comment
The enzyme, characterized from the bacterium Enterobacter agglomerans, is involved in biosynthesis of dapdiamide tripeptide antibiotics, a family of fumaramoyl- and epoxysuccinamoyl-peptides named for the presence of an (S)-2,3-diaminopropanoate (DAP) moiety and two amide linkages in their scaffold.
History
EC 6.3.2.46 created 2015
Reference
1  [PMID:19807062]
  Authors
Hollenhorst MA, Clardy J, Walsh CT
  Title
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
  Journal
Biochemistry. 48 (2009) 10467-72.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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