KEGG   ENZYME: 6.3.3.5Help
Entry
EC 6.3.3.5                  Enzyme                                 

Name
O-ureido-D-serine cyclo-ligase;
dcsG (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
BRITE hierarchy
Sysname
O-ureido-D-serine cyclo-ligase (D-cycloserine-forming)
Reaction(IUBMB)
O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate [RN:R10470]
Reaction(KEGG)
Substrate
O-ureido-D-serine [CPD:C20651];
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
D-cycloserine [CPD:C08057];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
History
EC 6.3.3.5 created 2013
Pathway
Biosynthesis of antibiotics
Orthology
K19727  
O-ureido-D-serine cyclo-ligase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for  the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob. Agents. Chemother. 54 (2010) 1132-9.
  Sequence
Reference
2  [PMID:23529730]
  Authors
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M
  Title
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
  Journal
Antimicrob. Agents. Chemother. 57 (2013) 2603-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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