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Entry
EC 6.3.3.7                  Enzyme                                 

Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
BRITE hierarchy
Sysname
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.3.7 created 2017
Pathway
Porphyrin and chlorophyll metabolism
Orthology
K21610  
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
K21611  
Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
MTH: 
MMG: 
METC: 
MWO: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MCUB: 
MFV: 
MKA: 
MK1385(nifD)
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
 » show all
Taxonomy
Reference
1  [PMID:3691535]
  Authors
Pfaltz A, Kobelt A, Huster R, Thauer RK
  Title
Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
  Journal
Eur. J. Biochem. 170 (1987) 459-67.
Reference
2  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science. 354 (2016) 339-342.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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